Results 121 to 130 of about 756,123 (346)

Quantitative Distribution Profile of Cadmium and Lead in Different Organs of Rats and Mitigation of their Accumulation Through Probiotic Treatment

Gut Microbes Reports
Cadmium (Cd) and lead (Pb) are toxic heavy metals that can have severe adverse effect on human health and environment. Pb contamination remains a significant concern due to its persistence in the environment, while Cd primarily enters the environment ...
Omprakash Omprakash, Rohit Kumar, Prashant Singh, Poonam Devi, Anuj Malik, Nitin Mahal   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

A Novel Function of Glycerol Kinase Alleviates LPS-Induced Inflammatory Responses by the p38/STAT3 Pathway and Mitigates ROS Generation in Kupffer Cells

Antioxidants
Kupffer cells (KCs), the predominant resident macrophages in the liver, exhibit an inflammatory activation state that is pathologically linked to various hepatic disorders.
Yanfei Li, Xu Zhang, Danping Wang, Guoqiang Fan, Xiaojing Yang   +4 more
doaj   +1 more source

Intravenous Toxicity Study of Water-soluble Ginseng Pharmacopuncture in SD Rats

Journal of Pharmacopuncture, 2015
Objectives: Radix Ginseng has been used for thousands of years to treat a wide variety of diseases. Radix ginseng has also been used as a traditional medicine for boosting Qi energy and tonifying the spleen and lungs.
Jun-Sang Yu, Seung-Ho Sun, Kwang-Ho Lee, Ki-Rok Kwon   +3 more
doaj   +1 more source

Clinical haematology, biochemistry profiles and erythrocytic morphometry of confiscated Sunda pangolins (Manis javanica) in the Centre for Rehabilitation and Quarantine of Confiscated Animals, Wildlife and Alien Species, Thailand

, 2023
Marnoch Yindee, W. Kelley Thomas, Worawidh Wajjawalku, Witsanu Wongsawang, Nicharee Income, Wantida Horpiencharoen, Nuttapon Bangkaew, Worapong Kosaruk, Wasinee Thepapichaikul, Wallaya Manatchaiworakul, Rattapan Pattanarangsan, Panthera Southeast and South Asia, Kanchanaburi 71000, Thailand, Dettachai Ketpun   +12 more
openalex   +2 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Genetic parameters of mule ducks meat and fatty liver performances simultaneously estimated in both parental liness : [Preprint] [PDF]

, 2009
Genetic parameters of traits related to hepatic lipid metabolism, carcass composition and products quality of overfed mule ducks were estimated on both parental lines of this hybrid: the "common duck" line (C), for the maternal side and the "Muscovy ...
André, J.M., Basso, B., Bastianelli, Denis, Baéza, Elisabeth, Bernadet, Marie-Dominique, Brun, J.M., Davail, S., Fernandez, Xavier, Guy, G., Legarra, Andrés, Marie-Etancelin, Christelle, Vitezica, Zulma G.   +11 more
core  

Urich, K. 1994. Comparative Animal Biochemistry. Springer Verlag, 782 pp. ISBN 3‐540‐57420‐4. [PDF]

, 1996
Maurice Wegnez
openalex   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source