Results 121 to 130 of about 352,615 (299)

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

EFFECTS OF SWEET ORANGE (CITRUS SINENSIS) WASTE MEAL IN RATION ON BLOOD GLUCOSE, CHOLESTEROL LEVEL IN MEAT QUAIL

open access: yesЖивотновъдни науки, 2014
Sweet orange waste, contain bioactive substances such as pectins, saponins, tannins, atsiri and flavonoids. This research has been conducted in the Faculty of Animal Husbandry Universitas Padjadjaran on August 5, 2013 until September 27, 2013.
LOVITA ADRIANI   +2 more
doaj  

Aplicação de PCR-RLFP para identificação de polimorfismos no gene do hormônio grelina de reprodutoras suínas [PDF]

open access: yes, 2014
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Agrárias. Curso de Zootecnia.A carne suína é a principal fonte de proteína animal do mundo, colocando o Brasil como destaque deste segmento ao deter o quarto maior plantel ...
Peripolli, Elisa
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The development of laboratory animal science and animal care of legislation and the consummation

open access: yes, 2012
Laboratory animal science is the use of non-human animals in experiments to obtain new knowledge and new technologies in biomedical research and testing.
Shizhong, Zhou
core  

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The Biochemistry of Animal Cells

open access: yesThe Journal of Biochemistry, 1964
Yoshiro Takeda   +3 more
openaire   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Session VIIIb Muscle Biochemistry and Meat Quality

open access: yes, 2015
EFFECT OF FROZEN STORAGE TIME ON QUALITY CHICKEN NUGGETS………………465 Teruel, R. ; Espinosa, M. ; Egea, M. ; Linares, M.B. ; Garrido, M.D. PROTEOME BASIS OF ANIMAL EFFECT ON COLOR STABILITY OF BEEF LONGISSIMUS LUMBORUM STEAKS……………………………………………………………..N/A ...
Editor, Managing
core  

Home - About - Disclaimer - Privacy