Results 141 to 150 of about 345,011 (254)

Efficient and safe lung gene delivery using AAV6.2FF in neonatal pigs demonstrates pediatric translational potential. [PDF]

Mol Ther Adv
Zielinska N, Howard EL, Yang C, Stevens BAY, Goens MM, Pei Y, Thompson B, Caswell JL, Thebaud B, Wey D, Valverde A, Arroyo LG, Wootton SK.   +12 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Influence of <i>Tectona grandis</i> leaf supplementation on growth, nutrient digestibility, serum biochemistry, hepatic antioxidant status, and cecal microbial profile in rabbits. [PDF]

Vet Anim Sci
Ahmed SA, Adeyemi KD.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Expression of the Cystatin SN (CST1) in Breast Cancer and Its Association With Clinical Characteristics: A Cross-Sectional Study. [PDF]

Cureus
Najnin S, Chowdhury NS, Ferdous R, Paul P, Islam J, Rahman MH.   +5 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Postmortem Aqueous Humor Analysis in Pigs as an Index of Antemortem Serum Biochemistry Profile and Diagnostic Aid in Animal Welfare. [PDF]

Animals (Basel)
Mihaljević Ž, Šandor K, Naletilić Š, Vidić Z, Kilvain I, Lolić M.   +5 more
europepmc   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Corrigendum to Spread of MCR-3 colistin resistance in China: an epidemiological, genomic and mechanistic study 2018 Aug; 34: 139-157. [PDF]

EBioMedicine
Xu Y, Zhong LL, Srinivas S, Sun J, Huang M, Paterson DL, Lei S, Lin J, Li X, Tang Z, Feng S, Shen C, Tian GB, Feng Y.   +13 more
europepmc   +1 more source

Effect of dietary supplementation with quercetin or rutin on the growth performance, meat quality and cecal microbiota of broilers under high stocking density. [PDF]

Vet Anim Sci
Zhao Y, Liu Y, Ning J, Li J, Dong Y.
europepmc   +1 more source