Results 131 to 140 of about 756,123 (346)

Compost and fertilizer mineralization effects on soil and harvest in parkland agroforestry systems in the south-Sudanese zone of Burkina Faso [PDF]

open access: yes, 2007
Decomposition of, and the subsequent nutrient release from tree leaf litter as well as external inputs of nutrients are important in the traditional agroforestry parklands of West Africa. The management of nutrient resources is essential to optimize crop
Gnankambary, Zacharia
core  

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

open access: yesMolecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal   +4 more
wiley   +1 more source

EFFECTS OF SWEET ORANGE (CITRUS SINENSIS) WASTE MEAL IN RATION ON BLOOD GLUCOSE, CHOLESTEROL LEVEL IN MEAT QUAIL

open access: yesЖивотновъдни науки, 2014
Sweet orange waste, contain bioactive substances such as pectins, saponins, tannins, atsiri and flavonoids. This research has been conducted in the Faculty of Animal Husbandry Universitas Padjadjaran on August 5, 2013 until September 27, 2013.
LOVITA ADRIANI   +2 more
doaj  

Florida marine biotechnology: research, development and training capabilities to advance science and commerce [PDF]

open access: yes, 2001
The level of activity and interest in “marine biotechnology” among Florida university faculty and allied laboratory scientists is reported in this document.
Seaman, William   +1 more
core  

In Search of the Neurobiological Substrates for Social Playfulness in Mammalian Brains

open access: yes, 2011
Play behavior is a fundamental and intrinsic neurobehavioral process in the mammalian brain. Using rough-and-tumble play in the juvenile rat as a model system to study mammalian playfulness, some of the relevant neurobiological substrates for this ...
Panksepp, Jaak, Siviy, Stephen M.
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

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