Results 241 to 250 of about 2,230,364 (263)

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

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Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer

Ca-A Cancer Journal for Clinicians, 2023
Miriam B. Garcia, Keri L Schadler, Steven K Clinton   +2 more
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Animal domestication in the era of ancient genomics

Nature Reviews Genetics, 2020
Laurent A F Frantz, Daniel G Bradley, Greger Larson   +2 more
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Animal models for HIV/AIDS research

Nature Reviews Microbiology, 2012
Theodora Hatziioannou, David T Evans
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Animal models for metabolic, neuromuscular and ophthalmological rare diseases

Nature Reviews Drug Discovery, 2013
Bruno Sepodes
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The evolution of signalling pathways in animal development

Nature Reviews Genetics, 2003
Andre Pires da Silva, Ralf J Sommer
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Can Animal Models of Disease Reliably Inform Human Studies?

PLoS Medicine, 2010
David Howells, Emily S Sena, Malcolm R Macleod   +2 more
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Animal models of neuropsychiatric disorders

Nature Neuroscience, 2010
Eric J Nestler, Steven E Hyman
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