Results 41 to 50 of about 344,168 (253)
Chemoprevention in experimental animals [PDF]
Annals of the New York Academy of Sciences, 2011 The potential cancer‐preventive effects of resveratrol, evident from the data obtained by various studies, are summarized in this review. Resveratrol (trans‐3,5,4′‐trihydroxystilbene), a naturally occurring polyphenolic compound, was first isolated in 1940 as a constituent of the roots of white Hellebore (Veratrum grandiflorumO. Loes), and is now found
openaire +3 more sources
FEBS Letters, EarlyView.Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek +15 more
wiley +1 more source
Alternatives to Laboratory Animals: Definition and Discussion [PDF]
, 1979 The origins of the concept of alternatives to the use of animals in research may be traced back to the 1800\u27s and the furore about using live animals in surgical and other experiments. Some of the animal protection societies in England were prepared
Rowan, Andrew N.
core +2 more sources
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Animal voices: Catherine Louisa Pirkis'The Experiences of Loveday Brooke, Lady Detective and the crimes of animality [PDF]
, 2018 While previous readings of Catherine Louisa Pirkis’ series The Experiences of Loveday Brooke, Lady Detective (1894) have focused on Brooke’s status as New Woman detective, this article considers the series in the context of Pirkis’ own ...
Pittard, Christopher
core +1 more source
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
Asbestosis in Experimental Animals [PDF]
Occupational and Environmental Medicine, 1963 Previous animal experiments with asbestos dusts have been almost entirely confined to chrysotile asbestos. It was, therefore, decided to investigate the effects of mill dusts from the three types of asbestos that are produced commercially in South Africa, namely chrysotile, amosite, and crocidolite.
openaire +3 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
The basis for standardization of animal experimentation [PDF]
, 1991 No abstract ...
Beynen, Anton C
core +3 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source