Results 71 to 80 of about 377,815 (340)

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Institutional animal care and use committees and the challenges of evaluating animal research proposals

open access: yesResearch Integrity and Peer Review
Background In the U.S. and many other countries, animal use in research, testing, and education is under the purview of Institutional Animal Care and Use Committees or similar bodies.
John J. Pippin   +8 more
doaj   +1 more source

Equine Activities Influence Horses’ Responses to Different Stimuli: Could This Have an Impact on Equine Welfare?

open access: yesAnimals, 2019
The learning and cognitive challenges that horses may face differ according to the activities in which they are involved. The aim of this investigation was to study the influence of equine activities on the behavioral responses and autonomic nervous ...
Tiago Mendonça   +5 more
doaj   +1 more source

Varieties of Exploratory Experimentation in Nanotoxicology [PDF]

open access: yes, 2008
There has been relatively little effort to provide a systematic overview of different forms of exploratory experimentation (EE). The present paper examines the growing subdiscipline of nanotoxicology and suggests that it illustrates at least four ways ...
Elliott, Kevin
core  

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Animal experimentation and scientific knowledge: a thought style?

open access: yesBrazilian Journal of Pharmaceutical Sciences, 2010
Animal experimentation, besides a research method extensively applied in the production of scientific knowledge, is also considered essential to science and with undeniable historical relevance in advances in human health. In this survey, a questionnaire
Thales de Astrogildo e Tréz
doaj   +1 more source

Code of good research practices [PDF]

open access: yes, 2010
Podeu consultar la versió en català a: http://hdl.handle.net/2445/28542 i en castellà a: http://hdl.handle.net/2445/28543As stated in its Statutes, one of the University of Barcelona's (UB) priority objectives is to carry out the highest level of ...
Universitat de Barcelona. Agència de Polítiques i de Qualitat
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Spending to Death: Wasteful Government Spending, Transparency Failures, and the Secretive World of Federal Dog Experiments [PDF]

open access: yes, 2016
"The Government Accountability Office has stated, "For decades…the public has been concerned that dogs and cats used in research could be treated inhumanely…"Indeed, in 1966, the U.S.

core  

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