Results 31 to 40 of about 371,602 (264)

Butyrate-producing commensal bacteria confers colon immune defense function via enhancing H4K31 Crotonylation of macrophages

Microbiome
Background The mechanisms by which microbiota from disease-resistant populations or animals improve intestinal immune defense remain incompletely elucidated.
Jianmin Wu, Pingting Guo, Minghui Wang, Zhaoyue Men, Zishen Lin, Jinping Wang, Shumin Zhang, Min Zhou, Jinbiao Zhao, Hu Liu, Xi Ma   +10 more
doaj   +1 more source

In Vivo Imaging of Rabbit Follicles through Combining Ultrasound Bio-Microscopy and Intravital Window

Animals
Continuous ovarian imaging has been proven to be a method for monitoring the development of follicles in vivo. The aim of this study was to evaluate the efficacy of combining ultrasound bio-microscopy (UBM) with an intravital window for follicle imaging ...
Lihan Yang, Chang Yan, Siming Tao, Yifeilong He, Jing Zhao, Yanya Wang, Yingjie Wu, Ning Liu, Yinghe Qin   +8 more
doaj   +1 more source

Polyphenol-rich diet mediates interplay between macrophage-neutrophil and gut microbiota to alleviate intestinal inflammation

Cell Death and Disease, 2023
Dietary phenolic acids alleviate intestinal inflammation through altering gut microbiota composition and regulating macrophage activation. However, it is unclear how individual phenolic acids affect the interactions between intestinal microbiota and ...
Dandan Han, Yujun Wu, Dongdong Lu, Jiaman Pang, Jie Hu, Xiangyu Zhang, Zhenyu Wang, Guolong Zhang, Junjun Wang   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

A combined strategy for high-efficiency expression of alkaline protease PrtA in Komagataella phaffii (syn. Pichia pastoris)

Microbial Cell Factories
Background Microbial serine proteases are valuable for industrial applications due to broad substrate specificity and stability. However, heterologous overexpression in microbial hosts is often limited by cytotoxicity and poor secretion.
Baozhen Zhao, Qiao Zhou, Panpan Wei, Honghai Zhang, Xing Qin, Tao Tu, Huoqing Huang, Bin Yao, Tao Dong, Huiying Luo   +9 more
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Night-restricted feeding preserves the ovarian circadian rhythm of IL-17 and promotes follicular development in prepubertal and pubertal rabbits

Journal of Ovarian Research
Background Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women.
Meng-Qi Zhu, Jian-Xiang Cheng, Chun-Hua Shan, Jie Huang, Ke-Hao Zhang, Yao Guo, Shuai He, Peng Liu, Zhong-Ying Liu, Zhong-Hong Wu   +9 more
doaj   +1 more source

Potential determinants of Clostridium spp. occurrence in Polish silage

Journal of Veterinary Research, 2020
Silage quality deteriorates with Clostridium spp. contamination, and if consumed, such silage jeopardises herd health and productivity. Minimising its occurrence reduces economic and animal welfare risks.
Goldsztejn Magdalena, Grenda Tomasz, Kozieł Nina, Sapała Magdalena, Mazur Małgorzata, Sieradzki Zbigniew, Król Beata, Kwiatek Krzysztof   +7 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source