Results 51 to 60 of about 1,007,760 (311)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Maternal fiber-rich diet promotes early-life intestinal development in offspring through milk-derived extracellular vesicles carrying miR-146a-5p

Journal of Nanobiotechnology
Backgrounds The intestinal development in early life is profoundly influenced by multiple biological components of breast milk, in which milk-derived extracellular vesicles (mEVs) contain a large amount of vertically transmitted signal from the mother ...
Dongdong Lu, Yisi Liu, Luyuan Kang, Xiangyu Zhang, Jie Hu, Hao Ye, Bingxu Huang, Yujun Wu, Jinbiao Zhao, Zhaolai Dai, Junjun Wang, Dandan Han   +11 more
doaj   +1 more source

In Vivo Imaging of Rabbit Follicles through Combining Ultrasound Bio-Microscopy and Intravital Window

Animals
Continuous ovarian imaging has been proven to be a method for monitoring the development of follicles in vivo. The aim of this study was to evaluate the efficacy of combining ultrasound bio-microscopy (UBM) with an intravital window for follicle imaging ...
Lihan Yang, Chang Yan, Siming Tao, Yifeilong He, Jing Zhao, Yanya Wang, Yingjie Wu, Ning Liu, Yinghe Qin   +8 more
doaj   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Butyrate-producing commensal bacteria confers colon immune defense function via enhancing H4K31 Crotonylation of macrophages

Microbiome
Background The mechanisms by which microbiota from disease-resistant populations or animals improve intestinal immune defense remain incompletely elucidated.
Jianmin Wu, Pingting Guo, Minghui Wang, Zhaoyue Men, Zishen Lin, Jinping Wang, Shumin Zhang, Min Zhou, Jinbiao Zhao, Hu Liu, Xi Ma   +10 more
doaj   +1 more source

Transfer of β‐agonists from animal feed into Tricholoma gambosum through manure

Animal Research and One Health, 2023
Fungi are dependent on animal manure as a cultivation medium and may be vulnerable to feed‐derived β‐agonist contamination. To test whether β‐agonists incorporated in animal feed can transport into fungi through manure, a greenhouse study was conducted ...
Yunsheng Han, Tengfei Zhan, Kai Zhang, Qingyu Zhao, Xiaoqing Guo, Chaohua Tang, Junmin Zhang   +6 more
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Feeding Habits of Wisconsin\u27s Predominant Lotic Plecoptera, Ephemeroptera, and Trichoptera [PDF]

, 2017
Feeding habits of nymphs or larvae of 101 species of Plecoptera, Ephemeroptera, and Trichoptera collected from Wisconsin\u27s streams were determined by examining foregut contents.
Hilsenhoff, William L, Shapas, Theodore J   +1 more
core   +3 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Night-restricted feeding preserves the ovarian circadian rhythm of IL-17 and promotes follicular development in prepubertal and pubertal rabbits

Journal of Ovarian Research
Background Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women.
Meng-Qi Zhu, Jian-Xiang Cheng, Chun-Hua Shan, Jie Huang, Ke-Hao Zhang, Yao Guo, Shuai He, Peng Liu, Zhong-Ying Liu, Zhong-Hong Wu   +9 more
doaj   +1 more source