Results 41 to 50 of about 2,401,595 (305)

Boosting the cellulolytic oxidative and hydrolytic enzyme systems in Myceliophthora thermophila for the efficient enzymatic saccharification of lignocellulosic biomass

Bioresources and Bioprocessing
The thermophilic fungus Myceliophthora thermophila serves as a vital platform for producing cellulolytic complex enzymes. However, their efficiency still requires enhancement to meet the cost-effective demands of lignocellulosic biomass conversion ...
Rui Bai, Kun Yang, Yaru Wang, Yuan Wang, Xiaolu Wang, Tao Tu, Jie Zhang, Xiaoyun Su, Huoqing Huang, Bin Yao, Huiying Luo, Xing Qin   +11 more
doaj   +1 more source

Effect of Calcareous Marine Algae Buffer on High-Producing Dairy Cows during Peak Lactation

Animals
The aim of the study was to investigate the effect of calcareous marine algae (Lithotamium calcareum)-based rumen content buffer (CMA) included in concentrated feed within total mixed ration (TMR), fed to 34 peak lactation (87–144 days in milk) Holstein ...
Radko Loučka, Václav Jambor, Hana Synková, Petr Homolka, Dana Kumprechtová, Veronika Koukolová, Petra Kubelková, Alena Výborná, Yvona Tyrolová, Filip Jančík   +9 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Night-restricted feeding preserves the ovarian circadian rhythm of IL-17 and promotes follicular development in prepubertal and pubertal rabbits

Journal of Ovarian Research
Background Irregular sleep and eating patterns in modern lifestyles may disrupt reproductive rhythms, thereby impairing reproductive function in adult women.
Meng-Qi Zhu, Jian-Xiang Cheng, Chun-Hua Shan, Jie Huang, Ke-Hao Zhang, Yao Guo, Shuai He, Peng Liu, Zhong-Ying Liu, Zhong-Hong Wu   +9 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A combined strategy for high-efficiency expression of alkaline protease PrtA in Komagataella phaffii (syn. Pichia pastoris)

Microbial Cell Factories
Background Microbial serine proteases are valuable for industrial applications due to broad substrate specificity and stability. However, heterologous overexpression in microbial hosts is often limited by cytotoxicity and poor secretion.
Baozhen Zhao, Qiao Zhou, Panpan Wei, Honghai Zhang, Xing Qin, Tao Tu, Huoqing Huang, Bin Yao, Tao Dong, Huiying Luo   +9 more
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

In vitro screening of nutrients regulating sheep intramuscular angiogenesis, adipogenesis, and lipid deposition using an organoid model

Journal of Animal Science and Biotechnology
Background The deposition of intramuscular fat (IMF) in livestock can enhance the flavor and tenderness of meat products, significantly increasing consumer satisfaction.
Yating Li, Xiaoying Sun, Yue Lv, Jiaxin Liu, Xinyi Mao, Jinyan Yu, Yanrong Feng, Long Cheng, Yifan Xiang, Yu Xin, Zhongzuo Huang, Yichen Luo, Yan Zhang, Junxing Zhao, Bo Wang   +14 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source