Results 61 to 70 of about 488,802 (265)

move2: R package for processing movement data

Methods in Ecology and Evolution
Studying animal movement is key to understanding ecological processes and studying the impacts of global change. The pivotal importance of collecting movement data drives technological development, and as a consequence, movement trajectories are gathered
Bart Kranstauber, Kamran Safi, Anne K. Scharf   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Captivity alters behaviour but not seasonal brain size change in semi-naturally housed shrews

Royal Society Open Science
Captivity, frequently used in animal research, can profoundly alter brain size, cognitive abilities and activity levels. Critically, persistent exposure to stressors in captive environments can lead to chronic stress and subsequently to a range of health
Cecilia Baldoni, Konstantinos Raptis, Marina Farantouri, Ivan Lenzi, Ka Sing Lim, Myles H. M. Menz, Marion Muturi, Marco Reisert, Maria Alejandra Bedoya Duque, William R. Thomas, Liliana M. Dávalos, John D. Nieland, Dominik von Elverfeldt, Dina K. N. Dechmann   +13 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Evolutionary Genetics of Animal Migration [PDF]

American Zoologist, 1991
Three primary approaches have been used to study the genetics of migration: the analyses of population differences, of single locus effects, and of polygenic influences. Studies of populations reared under similar conditions in “common garden” experiments frequently reveal gene effects contributing to differences in migratory tendency.
openaire   +1 more source

The influence of environmental conditions on the selection of spring migration routes by caribou

Ecosphere
Animal migrations influence key ecological processes such as predator–prey dynamics, nutrient and energy cycling, and community structure. Long‐distance migrations are declining worldwide, and a better understanding of the factors influencing animal ...
Cassandra Mac Hugh, Joëlle Taillon, Mathieu Leblond, Steeve D. Côté, Martin Leclerc   +4 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Individual Spatial Consistency and Dietary Flexibility in the Migratory Behavior of Northern Gannets Wintering in the Northeast Atlantic

Frontiers in Ecology and Evolution, 2019
Migration is a fundamental behavioral process prevalent among a wide variety of animal taxa. As individuals are increasingly shown to present consistent responses to environmental cues for breeding or foraging, it may be expected that approaches to ...
W. James Grecian, Hannah J. Williams, Hannah J. Williams, Stephen C. Votier, Stuart Bearhop, Ian R. Cleasby, Ian R. Cleasby, David Grémillet, David Grémillet, Keith C. Hamer, Mélanie Le Nuz, Amélie Lescroël, Amélie Lescroël, Jason Newton, Samantha C. Patrick, Richard A. Phillips, Ewan D. Wakefield, Thomas W. Bodey, Thomas W. Bodey   +18 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source