Results 61 to 70 of about 4,186,252 (300)

Distribution and Numbers of Three Globally Threatened Waterbird Species Wintering in Morocco: The Common Pochard, Marbled Teal, and White-Headed Duck

International Journal of Zoology, 2021
Morocco plays a key role in the life of many migratory birds and their survival, thanks to the diversity and richness of its ecosystems. The International Waterbird Census (IWC) has been regularly implemented in Morocco since 1983. Thanks to this program,
Asmaâ Ouassou, Mohamed Dakki, Mohammed-Aziz El Agbani, Abdeljebbar Qninba, R’himou El Hamoumi   +4 more
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

White stork movements reveal the ecological connectivity between landfills and different habitats

Movement Ecology, 2023
Background Connections between habitats are key to a full understanding of anthropic impacts on ecosystems. Freshwater habitats are especially biodiverse, yet depend on exchange with terrestrial habitats.
Cosme López-Calderón, Víctor Martín-Vélez, Julio Blas, Ursula Höfle, Marta I. Sánchez, Andrea Flack, Wolfgang Fiedler, Martin Wikelski, Andy J. Green   +8 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Mechanisms and Consequences of Partial Migration in Insects

Frontiers in Ecology and Evolution, 2019
Partial migration, where a proportion of a population migrates, while other individuals remain resident, is widespread across most migratory lineages.
Myles H. M. Menz, Myles H. M. Menz, Myles H. M. Menz, Myles H. M. Menz, Don R. Reynolds, Don R. Reynolds, Boya Gao, Boya Gao, Gao Hu, Jason W. Chapman, Jason W. Chapman, Jason W. Chapman, Karl R. Wotton   +12 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Sexual dimorphism in adult Little Stints (Calidris minuta) revealed by DNA sexing and discriminant analysis [PDF]

PeerJ, 2018
Background The sex of an individual organism plays such an important role in its life cycle that researchers must know a bird’s sex to interpret key aspects of its biology.
Aleksandra Niemc, Magdalena Remisiewicz, Joel Avni, Les G. Underhill   +3 more
doaj   +2 more sources

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Remote Sensing Data Reveal a Significant Reduction in the Area of the Nesting Habitat of Rafetus euphraticus in the Tigris River, Southeastern Turkey

Ecology and Evolution
The Euphrates Softshell Turtle (Rafetus euphraticus) is an endangered freshwater turtle native to the Tigris‐Euphrates river system. Habitat destruction caused by dams and sand mining poses a major threat to the species.
Murat Biricik, Kamran Safi, Şemsettin Turğa   +2 more
doaj   +1 more source