Results 31 to 40 of about 1,819,816 (315)

Generation of human induced pluripotent stem cells carrying albumin-sfGFP reporter

Stem Cell Research
Current methodologies for hepatocyte induction from human induced pluripotent stem cells (hiPSCs) have limited efficacy due to lack of a functional hepatocyte reporter.
Jinling Wang, Di Ye, Shuangpeng Li, Xuan Lu, Yue Chi, Chengcheng Tang, Xiaoqing Zhou, Min Chen, Yunwen Zheng, Jianyun Ge, Qingjian Zou   +10 more
doaj   +1 more source

Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model

Stem Cell Research & Therapy, 2021
Background Atherosclerosis (AS) is a complex disease caused in part by dyslipidemia and chronic inflammation. AS is associated with serious cardiovascular disease and remains the leading cause of mortality worldwide.
Yanhong Li, Guiying Shi, Yunlin Han, Haiquan Shang, Huiwu Li, Wei Liang, Wenjie Zhao, Lin Bai, Chuan Qin   +8 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Mathematical modelling in animal nutrition: a centenary review [PDF]

, 2008
A centenary review presents an opportunity to ponder over the processes of concept development and give thought to future directions. The current review aims to ascertain the ontogeny of current concepts, underline the connection between ideas and people
Dijkstra, J., Dumas, A., France, J., J. DIJKSTRA, A. DUMAS, J. FRANCE   +5 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease [PDF]

, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe.
Darci R. Smith, Joseph W. Golden, Aura R. Garrison   +2 more
core   +1 more source

A novel efficient strategy to generate liver sinusoidal endothelial cells from human pluripotent stem cells

Scientific Reports
Liver sinusoidal endothelial cells (LSECs) are highly specialized endothelial cells (ECs) that play an important role in liver development and regeneration. Additionally, it is involved in various pathological processes, including steatosis, inflammation,
Shang-Ping Tian, Jian-Yun Ge, Yu-Mu Song, Xiao-Qing Yu, Wen-Hao Chen, Yu-Ying Chen, Di Ye, Yun-Wen Zheng   +7 more
doaj   +1 more source

Neuroprotective effects of hypoactive Akkermansia muciniphila in MPTP-induced mouse models of Parkinson’s disease

Microbiology Spectrum
Parkinson’s disease (PD) has been associated with the microbiota-gut-brain axis, and probiotics have been shown to alleviate PD symptoms via various mechanisms.
Jiahui Xi, Chengcheng Tang, Xian Xiao, Min Chen, Qingjian Zou, Xiaoqing Zhou   +5 more
doaj   +1 more source

Animal Models for Candidiasis [PDF]

Current Protocols in Immunology, 2014
AbstractMultiple forms of candidiasis are clinically important in humans. Established murine models of disseminated, oropharyngeal, vaginal, and cutaneous candidiasis caused by Candida albicans are described in this unit. Detailed materials and methods for C. albicans growth and detection are also described. Curr. Protoc. Immunol. 105:19.6.1‐19.6.17. ©
Heather R, Conti, Anna R, Huppler, Natasha, Whibley, Sarah L, Gaffen   +3 more
openaire   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source