Results 31 to 40 of about 21,434 (259)

Comparative analysis of image quality parameters and spatial resolution of three Small Animal PET scanner in Brazil

Brazilian Journal of Radiation Sciences, 2023
This study evaluated Image Quality (IQ) parameters and spatial resolution (SR) of Triumph® LabPET systems installed in three different Brazilian preclinical molecular imaging centers.
Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira, Daniele Faria, Carlos Alberto Buchpiguel, Samuel Greggio, Gianina Venturin, Jader Costa, Juliana Silva, Marcelo Mamede   +8 more
doaj   +1 more source

Comparing quantitative image parameters between animal and clinical CT-scanners: a translational phantom study analysis

Frontiers in Medicine
PurposeThis study compares phantom-based variability of extracted radiomics features from scans on a photon counting CT (PCCT) and an experimental animal PET/CT-scanner (Albira II) to investigate the potential of radiomics for translation from animal ...
Abhinay Vellala, Carolin Mogler, Florian Haag, Fabian Tollens, Henning Rudolf, Friedrich Pietsch, Carmen Wängler, Björn Wängler, Stefan O. Schoenberg, Matthias F. Froelich, Alexander Hertel   +10 more
doaj   +1 more source

Noninvasive visualization of the activated alphavbeta3 integrin in cancer patients by positron emission tomography and [18F]Galacto-RGD. [PDF]

PLoS Medicine, 2005
BACKGROUND: The integrin alphavbeta3 plays an important role in angiogenesis and tumor cell metastasis, and is currently being evaluated as a target for new therapeutic approaches.
Roland Haubner, Wolfgang A Weber, Ambros J Beer, Eugenija Vabuliene, Daniel Reim, Mario Sarbia, Karl-Friedrich Becker, Michael Goebel, Rüdiger Hein, Hans-Jürgen Wester, Horst Kessler, Markus Schwaiger   +11 more
doaj   +1 more source

An in vivo multimodal feasibility study in a rat brain tumour model using flexible multinuclear MR and PET systems

EJNMMI Physics, 2020
Background In addition to the structural information afforded by 1H MRI, the use of X-nuclei, such as sodium-23 (23Na) or phosphorus-31 (31P), offers important complementary information concerning physiological and biochemical parameters.
Chang-Hoon Choi, Carina Stegmayr, Aliaksandra Shymanskaya, Wieland A. Worthoff, Nuno A. da Silva, Jörg Felder, Karl-Josef Langen, N. Jon Shah   +7 more
doaj   +1 more source

Optimised motion tracking for positron emission tomography studies of brain function in awake rats. [PDF]

PLoS ONE, 2011
Positron emission tomography (PET) is a non-invasive molecular imaging technique using positron-emitting radioisotopes to study functional processes within the body. High resolution PET scanners designed for imaging rodents and non-human primates are now
Andre Z Kyme, Victor W Zhou, Steven R Meikle, Clive Baldock, Roger R Fulton   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Performance Evaluation of Small Animal PET Scanners With Different System Designs [PDF]

IEEE Transactions on Nuclear Science, 2013
This study evaluated the image quality metrics of small animal PET scanners based upon measured single detector module positioning performance. A semi-analytical approach was developed to study PET scanner performance in the scenario of multiple realizations.
Xiaoli, Li, Adam M, Alessio, Thompson H, Burnett, Thomas K, Lewellen, Roberts, Miyaoka   +4 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Perfomance analysis of a small animal PET scanner using 68Ga Isotope

Brazilian Journal of Radiation Sciences
In recent years, the use of PET scanners for small animals in preclinical research has been growing in Brazil, due to this fact it is essential to have a quality assurance program to ensure the good performance of these scanners or indicate the need for
Victória Garcia Moreira, Anna Clara Moreira Silva, Rodrigo Modesto Gadelha Gontijo, Andréa Vidal Ferreira   +3 more
doaj   +1 more source

Imaging the Vasculature of Immunodeficient Mice Using Positron Emission Tomography/Computed Tomography (PET/CT) and 18F-fluorodeoxyglucose Labeled Human Erythrocytes

Bio-Protocol, 2019
Nuclear blood pool imaging using radiolabeled red blood cells has been used in the clinical setting for the evaluation of a number of medical conditions including gastrointestinal hemorrhage, impaired cardiac contractility, and altered cerebrovascular ...
Shaowei Wang, Jung Choi
doaj   +1 more source