Results 91 to 100 of about 1,128,692 (290)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Ocean warming drives tissue-wide metabolic reprogramming in a fish
iScienceSummary: Ocean warming and marine heatwaves are predicted to have adverse impacts on marine organisms. Yet, knowledge of the molecular mechanisms that underpin successful or failed acclimation to increasing temperatures remains incomplete.
Billy Moore +4 more
doaj +1 more source
Comparative Animal Physiology [PDF]
Nature, 1953 Comparative Animal Physiology By Prof. David W. Bishop, Prof. Frank A. Brown Jr., Prof. Theodore L. Jahn, Prof. C. Ladd Prosser and Prof. Verner J. Wulff. Prof. C. Ladd Prosser, Editor. Pp. ix + 888. (Philadelphia and London: W. B. Saunders Co., 1950.) 63s.
openaire +1 more source
Breed differences in the number and kinds of leucocytes in blood of swine [PDF]
, 1960 This bulletin reports on Department of Animal Husbandry Research Project 222, 'Swine Improvement, ' and Department of Agricultural Chemistry Research Project 223, 'Reproductive Physiology'--P.
Milicevic, Mike
core
Does individual variation in metabolic phenotype predict fish behaviour and performance? [PDF]
, 2015 There is increasing interest in documenting and explaining the existence of marked intraspecific variation in metabolic rate in animals, with fishes providing some of the best-studied examples.
Killen, S. S. +2 more
core +1 more source
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
F1000Research, 2014 Previous research identified a locus on Chromosome 14 as an important regulator of endurance exercise capacity in mice. The aim of this study was to investigate the effect of chromosome substitution on intrinsic exercise capacity and identify ...
Sean M. Courtney, Michael P. Massett
doaj +1 more source