A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics [PDF]
, 2019 Cellular, organ, and whole animal physiology show temporal variation predominantly featuring 24-h (circadian) periodicity. Time-course mRNA gene expression profiling in mouse liver showed two subsets of genes oscillating at the second (12-h) and third (8-
Biagini, Tommaso +11 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
The role of physiological traits in assortment among and within fish shoals [PDF]
, 2017 Individuals of gregarious species often group with conspecifics to which they are phenotypically similar. This among-group assortment has been studied for body size, sex and relatedness.
Domenici, Paolo +3 more
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Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Physiology of man and animals in the Tenth Five-Year Plan: Proceedings of the Thirteenth Congress of the I. P. Pavlov All-Union Physiological Society [PDF]
Research in the field of animal and human physiology is reviewed. The following topics on problems of physiological science and related fields of knowledge are discussed: neurophysiology and higher nervous activity, physiology of sensory systems ...
Lange, K. A.
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Lifetime glucocorticoid profiles in baleen of right whale calves: Potential relationships to chronic stress of repeated wounding by Kelp Gulls [PDF]
, 2018 Baleen tissue accumulates stress hormones (glucocorticoids, GC) as it grows, along with other adrenal, gonadal and thyroid hormones. The hormones are deposited in a linear fashion such that a single plate of baleen allows retrospective assessment and ...
Ajó, Alejandro A. Fernández +7 more
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Development of Professional Skills through Subject Animal Anatomophysiology
Agrisost, 2019 Context: One of the most important problems of pedagogical work in higher education is the process of professional skills training, which is part of professional education, in which scientific information should be applied in a creative manner to provide
Humberto B. Sóñora Revoredo +4 more
doaj
iScienceSummary: Milk fat is an important indicator for evaluating the quality of cow’s milk. In this study, we used bovine mammary epithelial cells (BMECs) to investigate the role and molecular mechanism of KLF4 in the regulation of milk fat synthesis.
Hong-Yu Wu +6 more
doaj +1 more source
Male sexually coercive behaviour drives increased swimming efficiency in female guppies [PDF]
, 2015 Sexual coercion of females by males is widespread across sexually reproducing species. It stems from a conflict of interest over reproduction and exerts selective pressure on both sexes.
Croft, Darren P. +3 more
core +2 more sources