Results 251 to 260 of about 754,514 (306)
Some of the next articles are maybe not open access.
Replacing animal experiments: choices, chances and challenges
BioEssays, 2007AbstractReplacing animal procedures with methods such as cells and tissues in vitro, volunteer studies, physicochemical techniques and computer modelling, is driven by legislative, scientific and moral imperatives. Non‐animal approaches are now considered as advanced methods that can overcome many of the limitations of animal experiments.
Langley, Gill +3 more
openaire +3 more sources
The Replacement of Animal Tests
Alternatives to Laboratory Animals, 2018Progress toward the acceptance and application of validated alternative test methods as replacements for animal tests, is being frustrated by the unsatisfactory procedures involved in approving new test guidelines and deleting existing ones
openaire +2 more sources
Animal Studies of Surfactant Replacement Therapy
Developmental Pharmacology and Therapeutics, 1989Before using surfactant preparations in animal experiments or in clinical trials, it is necessary that they fulfil specific in vivo requirements. But conclusive criteria for the effectiveness of a surfactant have not yet been defined. Thus, some standard levels for improvement of lung function, or threshold levels, must be established in standardized ...
openaire +2 more sources
Technology Feature | Replacing the replacements: Animal model alternatives
Science, 2018Advances in biosensors and microfluidic devices are driving a quiet revolution in biomedical research, which could lead to the reduction or elimination of animal use in many experiments..
openaire +1 more source
Non-animal Replacements for Acute Toxicity Testing
Alternatives to Laboratory Animals, 2015Current approaches to predicting adverse effects in humans from acute toxic exposure to cosmetic ingredients still heavily necessitate the use of animals under EU legislation, particularly in the context of the REACH system, when cosmetic ingredients are also destined for use in other industries.
Carol, Barker-Treasure +6 more
openaire +2 more sources
Diaphragm replacement: An experimental animal study
Hernia, 1997We performed an open experimental study for evaluation of rapidly absorbable material of bovine serosa for diaphragm replacement. A total of 100 Sprague-Dawley rats were randomly assigned to five groups of equal size. In the control group (n=20) incision of the diaphragm was followed by primary suture.
G. Steinau +4 more
openaire +2 more sources
Strategies for replacing animals in biomedical research
Molecular Medicine Today, 1997In 1959, Russell and Burch published their recommendations for applying the Three Rs (reduction, refinement and replacement alternatives) to the use of animals in scientific experimentation. At this time, they could not have predicted the effect of this fundamental concept on academic and industrial animal experimentation and in biomedical education ...
C L, Broadhead, K, Bottrill
openaire +2 more sources
Replacing experiments on laboratory animals
Trends in Biochemical Sciences, 1986There is great scope for overcoming the moral dilemma inherent in experiments using live animals by reducing the numbers of animals required, minimizing any suffering caused, and, in many cases, replacing them altogether through the development, validation and application of alternative methods.
openaire +1 more source
1989
People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
openaire +1 more source
People seeking change on behalf of animals in laboratories can be broadly categorised as abolitionists or reformists. Abolitionists seek to ban all animal experiments, or at least those experiments that are not in the best interests of the animal subjects.
openaire +1 more source
Towards Finding Animal Replacement Methods
2017Protecting animal rights and reducing animal suffering in experimentation is a globally recognized goal in science. Yet numbers have been rising, especially in basic research. While most scientists agree that they would prefer to use less invasive methods, studies have shown that current information systems are not equipped to support the search for ...
Dulisch, Nadine, Mathiak, Brigitte
openaire +1 more source