Results 211 to 220 of about 5,358,841 (304)

Advocating for automation in animal research: using home cage monitoring to advance welfare, reproducibility and scientific openness.

Dis Model Mech
COST Action TEATIME CA20135 welfare group.
europepmc   +1 more source

Non-verbal effecting - animal research sheds light on human emotion communication. [PDF]

Biol Rev Camb Philos Soc
Schirmer A, Croy I, Liebal K, Schweinberger SR.   +3 more
europepmc   +1 more source

Suppression of the immune system in trypanosomiasis [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Noise as an Extrinsic Variable in the Animal Research Facility. [PDF]

J Am Assoc Lab Anim Sci
Turner JG, Manker JR.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

One R or the other - an experimental bioethics approach to 3R dilemmas in animal research. [PDF]

Med Health Care Philos
Rodriguez Perez C, Shaw DM, Earp BD, Elger BS, Persson K.   +4 more
europepmc   +1 more source

How trypanosomes tolerate drugs that once killed them [PDF]

, 2012
International Laboratory for Research on Animal Diseases
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Safety of Alcohol Pharmacotherapies in Pregnancy: A Scoping Review of Human and Animal Research. [PDF]

CNS Drugs
Quintrell E, Russell DJ, Rahmannia S, Wyrwoll CS, Larcombe A, Kelty E.   +5 more
europepmc   +1 more source