Results 11 to 20 of about 282,052 (348)
Animal testing alternatives come alive in US [PDF]
Nature Medicine, 2010 Elie Dolgin
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Frontiers in Toxicology, 2023 Introduction: The positive identification of xenobiotics and their metabolites in human biosamples is an integral aspect of exposomics research, yet challenges in compound annotation and identification continue to limit the feasibility of comprehensive ...
Breanne Kincaid +6 more
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Frontiers in Artificial Intelligence, 2021 Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran +6 more
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Frontiers in Cellular Neuroscience, 2023 IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero +6 more
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Recent advances in directional statistics [PDF]
, 2020 Mainstream statistical methodology is generally applicable to data observed in Euclidean space. There are, however, numerous contexts of considerable scientific interest in which the natural supports for the data under consideration are Riemannian ...
García-Portugués, Eduardo +1 more
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Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
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Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease
EMBO Molecular Medicine, 2023 Human health is determined both by genetics (G) and environment (E). This is clearly illustrated in groups of individuals who are exposed to the same environmental factor showing differential responses.
Alessio Butera +6 more
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Antidepressant Paroxetine Exerts Developmental Neurotoxicity in an iPSC-Derived 3D Human Brain Model
Frontiers in Cellular Neuroscience, 2020 Selective serotonin reuptake inhibitors (SSRIs) are frequently used to treat depression during pregnancy. Various concerns have been raised about the possible effects of these drugs on fetal development.
Xiali Zhong +15 more
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Biomimetic heart platforms for drug development [PDF]
Organoid, 2022 New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects.
Sungwoo Cho, Sungho Ko
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Frontiers in Genetics, 2018 Despite Bisphenol-A (BPA) being subject to extensive study, a thorough understanding of molecular mechanism remains elusive. Here we show that using weighted gene correlation network analysis (WGCNA), which takes advantage of a graph theoretical approach
Alexandra Maertens +5 more
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