Predicting toxicity of chemicals: software beats animal testing
EFSA Journal, 2019 We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
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Replacement Strategies for Animal Studies in Inhalation Testing
Sci, 2021 Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
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Animal Ethics and India: Understanding the Connection through the Capabilities Approach [PDF]
, 2017 This paper, unveiling the visionary short-sightedness of animal protection, argues for a just vision towards animals in India. Critically analysing the wide range of animal protections in India, the paper finds that in spite of such protections, animals ...
Chakraborty, Rhyddhi
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Author Guide for Addressing Animal Methods Bias in Publishing
Advanced Science, 2023 There is growing recognition that animal methods bias, a preference for animal‐based methods where they are not necessary or where nonanimal‐based methods may already be suitable, can impact the likelihood or timeliness of a manuscript being accepted for
Catharine E. Krebs +8 more
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Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods [PDF]
Genomics & Informatics, 2020 Finding publications that propose alternative methods to animal experiments is an important but time-consuming task since researchers need to perform various queries to literature databases and screen many articles to assess two important aspects: the ...
Mariana Neves
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Brain organoids and organoid intelligence from ethical, legal, and social points of view
Frontiers in Artificial IntelligenceHuman brain organoids, aka cerebral organoids or earlier “mini-brains”, are 3D cellular models that recapitulate aspects of the developing human brain.
Thomas Hartung +3 more
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EURL ECVAM Strategy to replace, reduce and refine the use of fish in aquatic toxicity and bioaccumulation testing [PDF]
, 2014 The assessment of aquatic toxicity and bioaccumulation are important components of the environmental hazard and risk assessment of all types of chemicals, and are therefore included in several pieces of European Union and international legislation.
HALDER MARIA ELISABETH +3 more
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Communications BiologyBrain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Dowlette-Mary Alam El Din +13 more
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RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies
Frontiers in Pharmacology, 2022 By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes ...
Mieke Van Mulders +5 more
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Progress Toward Replacing Animals in Toxicity Testing for Cosmetics [PDF]
, 2012 In the 1980’s, animal rights activists successfully motivated the cosmetic industry to begin researching alternatives to animal tests.
Nye, Marisa B.
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