Results 11 to 20 of about 455 (211)
Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
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Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
iScience, 2020 Summary: Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient ...
David Pamies +2 more
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Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
Frontiers in Microbiology, 2018 Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions.
Celina Monteiro Abreu +9 more
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Biomimetic heart platforms for drug development [PDF]
Organoid, 2022 New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects.
Sungwoo Cho, Sungho Ko
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Predicting toxicity of chemicals: software beats animal testing
EFSA Journal, 2019 We created earlier a large machine‐readable database of 10,000 chemicals and 800,000 associated studies by natural language processing of the public parts of Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) registrations until
Thomas Hartung
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Animal Testing Alternatives: Online Resources
Issues in Science and Technology Librarianship, 2000 This article focuses on bibliographic databases and web sites that provide information on the scientific aspects of animal testing alternatives and not on the pros and cons of animal rights.
Elizabeth Choinski
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Towards learning and memory risk assessment with human brain organoids: barriers and opportunities
Frontiers in ToxicologyNeurodevelopmental conditions, including autism spectrum disorder, intellectual disability, and learning disabilities, as well as neurodegenerative disorders, affect millions of people in the United States alone.
Ronit Mohapatra +6 more
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Brain organoids and organoid intelligence from ethical, legal, and social points of view
Frontiers in Artificial IntelligenceHuman brain organoids, aka cerebral organoids or earlier “mini-brains”, are 3D cellular models that recapitulate aspects of the developing human brain.
Thomas Hartung +3 more
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Communications BiologyBrain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Dowlette-Mary Alam El Din +13 more
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Frontiers in ToxicologyComputational models for skin sensitization prediction face critical challenges in handling activity cliffs, where structurally similar compounds exhibit different biological activities, limiting their regulatory applicability.
Daniel C. Ukaegbu +3 more
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