Results 11 to 20 of about 57,035 (299)

In silico methods – Computational alternatives to animal testing [PDF]

ALTEX, 2018
A seminar and interactive workshop on “In silico Methods – Computational Alternatives to Animal Testing” was held in Berlin, Germany, organized by Annemarie Lang, Frank Butt- gereit and Andrea Volkamer at the Charite-Universitatsmedizin Berlin, on August 17-18, 2017. During the half-day seminar, the variety and applications of in silico methods as
Lang, Annemarie, Volkamer, Andrea, Behm, Laura, Roblitz, Susanna, Ehrig, Rainald, Schneider, Marlon, Geris, Liesbet, Wichard, Joerg, Buttgereit, Frank   +8 more
openaire   +4 more sources

Medical Devices Biological Safety Assessment: Towards Animal-free Testing [PDF]

Derecho Animal, 2019
Animals have been used since a very long time as experimental subjects to support scientific progress and medical advances. Currently, various testing procedures implying animals are still being conducted within a broad range of scientific fields and ...
Nadège Sachot, Augusto Vitale
doaj   +3 more sources

Non-animal models of epithelial barriers (skin, intestine and lung) in research, industrial applications and regulatory toxicology [PDF]

, 2022
S.327-378Models of the outer epithelia of the human body - namely the skin, the intestine and the lung - have found valid applications in both research and industrial settings as attractive alternatives to animal testing. A variety of approaches to model
Fabian, E., Kandarova, H., Gordon, S., Khare, S., Marx, U., Prieto, P., Leist, M., Caloni, F., Constant, S., Hartung, T., Krug, H.F., Davies, D.E., Tralau, T., Guzman, C.A., Metzger, M., Roggen, E.L., Daneshian, M., Lehr, C.-M., Hasiwa, N., Roberts, M.S., Kneuer, C., Hayden, P., Dandekar, G., Walles, Heike, Bouwstra, J., Ott, K., Lian, G., Braak, C. van den, Haltner, E.   +28 more
core   +1 more source

Associations between clinical signs and pathological findings in toxicity testing [PDF]

, 2021
Animal testing for toxicity assessment of chemicals and pharmaceuticals must take the 3R principles into consideration. During toxicity testing in vivo, clinical signs are used to monitor animal welfare and to inform about potential toxicity.
Silva, Antero Vieira,, Silva, Antero, V,, Liiv, E, Tornqvist, E, Öberg, Mattias,, Liiv, Elin,, Törnqvist, Elin,, Öberg, Mattias, Platzack, Björn,, Silva, Antero, Platzack, Björn, Norinder, U, Liiv, Elin, Törnqvist, Elin, Silva, AV, Platzack, B, Oberg, M, Norinder, Ulf,   +17 more
core   +1 more source

Alternative methods for the replacement of eye irritation testing [PDF]

, 2022
S.55-67In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye.
Wever, Bart de, Walles, Heike, Groeber-Becker, Florian, Schmid, Freia F., Kampik, Daniel, Kurdyn, Szymon, Lotz, Christian, Rossi, Angela   +7 more
core   +1 more source

Artificial intelligence as the new frontier in chemical risk assessment

Frontiers in Artificial Intelligence, 2023
The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
doaj   +1 more source

Suitability of 3D human brain spheroid models to distinguish toxic effects of gold and poly-lactic acid nanoparticles to assess biocompatibility for brain drug delivery

Particle and Fibre Toxicology, 2019
Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite, Mariana Rodrigues Pereira, Georgina Harris, David Pamies, Lisia Maria Gobbo dos Santos, José Mauro Granjeiro, Helena T. Hogberg, Thomas Hartung, Lena Smirnova   +8 more
doaj   +1 more source

Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem

iScience, 2020
Summary: Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient ...
David Pamies, Marie-Gabrielle Zurich, Thomas Hartung   +2 more
doaj   +1 more source

Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres

Frontiers in Microbiology, 2018
Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions.
Celina Monteiro Abreu, Lucio Gama, Lucio Gama, Susanne Krasemann, Megan Chesnut, Shelly Odwin-Dacosta, Helena T. Hogberg, Thomas Hartung, Thomas Hartung, David Pamies   +9 more
doaj   +1 more source

Biomimetic heart platforms for drug development [PDF]

Organoid, 2022
New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects.
Sungwoo Cho, Sungho Ko
doaj   +1 more source