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Recent Developments in Alternatives to Animal Testing [PDF]
Animal Experimentation: Working Towards a Paradigm Change, 2019 At least 115 million animals are thought to be used for scientific purposes every year, worldwide (Taylor et al., 2008). Animals are typically used to test whether an intervention will cause harm to humans or other animals of the same or different ...
Katy Taylor
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Frontiers in Artificial Intelligence, 2021 Failure to adequately characterize cell lines, and understand the differences between in vitro and in vivo biology, can have serious consequences on the translatability of in vitro scientific studies to human clinical trials.
Vy Tran +6 more
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FDA no longer has to require animal testing for new drugs
Science, 2023 Description Agency can rely on animal-free alternatives before human trials Agency can rely on animal-free alternatives before human ...
M. Wadman
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Frontiers in Cellular Neuroscience, 2023 IntroductionOligodendrocytes (OLs) are the myelin-forming cells of the central nervous system (CNS). Although OLs can be differentiated from human-induced pluripotent stem cells (hiPSCs), the in vitro modeling of axon myelination in human cells remains ...
July Carolina Romero +6 more
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Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing
International Journal of Molecular Sciences, 2021 Millions of experimental animals are widely used in the assessment of toxicological or biological effects of manufactured nanomaterials in medical technology. However, the animal consciousness has increased and become an issue for debate in recent years.
Hung-Jin Huang +5 more
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Biomimetic heart platforms for drug development [PDF]
Organoid, 2022 New drug development is currently very expensive and time-consuming. In addition, some drugs that are approved after animal and clinical trials have their approval revoked because of adverse effects.
Sungwoo Cho, Sungho Ko
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Artificial intelligence as the new frontier in chemical risk assessment
Frontiers in Artificial Intelligence, 2023 The rapid progress of AI impacts various areas of life, including toxicology, and promises a major role for AI in future risk assessments. Toxicology has shifted from a purely empirical science focused on observing chemical exposure outcomes to a data ...
Thomas Hartung, Thomas Hartung
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A History of Regulatory Animal Testing: What Can We Learn?
Alternatives to laboratory animals : ATLA, 2022 The contemporary pharmaceutical industry is voicing growing concerns about the translatability and reproducibility of animal models. In addition, the usefulness of certain of the required regulatory safety tests in animals is being increasingly ...
Doortje Swaters +4 more
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Deconvoluting gene and environment interactions to develop an “epigenetic score meter” of disease
EMBO Molecular Medicine, 2023 Human health is determined both by genetics (G) and environment (E). This is clearly illustrated in groups of individuals who are exposed to the same environmental factor showing differential responses.
Alessio Butera +6 more
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Alternatives to laboratory animals : ATLA, 2020 Across the spectrum of industrial sectors, including pharmaceuticals, chemicals, personal care products, food additives and their associated regulatory agencies, there is a need to develop robust and reliable methods to reduce or replace animal testing ...
J. Madden, S. Enoch, A. Paini, M. Cronin
semanticscholar +1 more source