An Overview of Tissue Engineering as an Alternative for Toxicity Assessment [PDF]
, 2016 Tissue engineering is a multidisciplinary field that combines aspects of biology, material sciences, engineering and medicine - the ultimate goal being able to fabricate replacement tissues and/or organs for an ageing population.
Chau, David Y.S., Garrod, Mathew
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Particle and Fibre Toxicology, 2019 Background The blood brain barrier (BBB) is the bottleneck of brain-targeted drug development. Due to their physico-chemical properties, nanoparticles (NP) can cross the BBB and accumulate in different areas of the central nervous system (CNS), thus are ...
Paulo Emílio Corrêa Leite +8 more
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Organotypic Models to Study Human Glioblastoma: Studying the Beast in Its Ecosystem
iScience, 2020 Summary: Glioblastoma is a very aggressive primary brain tumor in adults, with very low survival rates and no curative treatments. The high failure rate of drug development for this cancer is linked to the high-cost, time-consuming, and inefficient ...
David Pamies +2 more
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Microglia Increase Inflammatory Responses in iPSC-Derived Human BrainSpheres
Frontiers in Microbiology, 2018 Human induced pluripotent stem cells (iPSCs), together with 21st century cell culture methods, have the potential to better model human physiology with applications in toxicology, disease modeling, and the study of host-pathogen interactions.
Celina Monteiro Abreu +9 more
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Replacement Strategies for Animal Studies in Inhalation Testing
Sci, 2021 Animal testing is mandatory in drug testing and is the gold standard for toxicity and efficacy evaluations. This situation is expected to change in the future as the 3Rs principle, which stands for the replacement, reduction, and refinement of the use of
Eleonore Fröhlich
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Integration of the PubAnnotation ecosystem in the development of a web-based search tool for alternative methods [PDF]
Genomics & Informatics, 2020 Finding publications that propose alternative methods to animal experiments is an important but time-consuming task since researchers need to perform various queries to literature databases and screen many articles to assess two important aspects: the ...
Mariana Neves
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Animal Ethics and India: Understanding the Connection through the Capabilities Approach [PDF]
, 2017 This paper, unveiling the visionary short-sightedness of animal protection, argues for a just vision towards animals in India. Critically analysing the wide range of animal protections in India, the paper finds that in spite of such protections, animals ...
Chakraborty, Rhyddhi
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In Vitro Antimicrobial Activities of Organic Acids and Their Derivatives on Several Species of Gram-Negative and Gram-Positive Bacteria. [PDF]
, 2019 The objective of this study was to determine the in vitro antimicrobial activity of several organic acids and their derivatives against Gram-positive (G+) and Gram-negative (G-) bacteria.
Atwill, Edward Robert +8 more
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Author Guide for Addressing Animal Methods Bias in Publishing
Advanced Science, 2023 There is growing recognition that animal methods bias, a preference for animal‐based methods where they are not necessary or where nonanimal‐based methods may already be suitable, can impact the likelihood or timeliness of a manuscript being accepted for
Catharine E. Krebs +8 more
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RE-Place: A Unique Project Collecting Expertise on New Approach Methodologies
Frontiers in Pharmacology, 2022 By applying “New Approach Methodologies (NAMs)” based on innovative technologies such as computer modeling, high throughput testing, omics, and sophisticated cell cultures, the use of experimental animals in the life sciences can be reduced or sometimes ...
Mieke Van Mulders +5 more
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