Results 111 to 120 of about 747,053 (355)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Scientific Opinion on the use of animal‐based measures to assess welfare of dairy cows

EFSA Journal, 2012
Animal‐based measures, identified on the basis of scientific evidence, can be effectively used in the evaluation of the welfare of dairy cattle on farm in relation to laws, codes of practice, quality assurance schemes and management.
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

Adolescents care but don't feel responsible for farm animal welfare [PDF]

, 2015
Adolescents are the next generation of consumers with the potential to raise standards of farm animal welfare—to theirsatisfaction—if their preferences and concerns are translated into accurate market drivers and signals.
Abeyesinghe, S M, Allen, D, Asher, L, IOE, Jamieson, J, Nottingham, Parker, M O, Queen Mary London, Reiss, M J, RSPCA, Wathes, C M   +10 more
core   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The dialogue with farmers [PDF]

, 2011
This report covers the project outcome Deliverable 4.2 ‘Analysis completed after a joint effort to identify possibilities in each country as how to facilitate the best possible dialogue regarding animal health and welfare’ as part of the European CORE ...
Brinkmann, Jan, Gratzer, Elisabeth, Henriksen, Britt I. F., Ivemeyer, Silvia, Leeb, Christine, March, Solveig, Mejdell, Cecilie, Nicholas, Phillipa, Roderick, Stephen, Smolders, Gidi, Stöger, Elisabeth, Vaarst, Mette, Walkenhorst, Michael, Whistance, Lindsay, Winckler, Christoph   +14 more
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Use of high concentrations of carbon dioxide for stunning rabbits reared for meat production

World Rabbit Science, 2016
: An investigation was performed to determine whether high concentrations of carbon dioxide (CO2) at 70-98% in atmospheric air are a suitable alternative for stunning rabbits compared to conventional approaches such as electronarcosis.
A. Dalmau, J. Pallisera, C. Pedernera, I. Muñoz, R. Carreras, N. Casal, E. Mainau, P. Rodriguez, A. Velarde   +8 more
doaj   +1 more source

The role of attending veterinarians in laboratory animal welfare [PDF]

, 1995
Fred W. Quimby
openalex   +1 more source

Assessment of the Welfare of Extensively Managed Autochtonous Sheep Breed Vlasicka Zackel using Animal-Based Measurements [PDF]

, 2020
Katarina Nenadović, Karać Petar, Marijana Vučinić, Radislava Teodorović, Živanov Dragan, Ružica Trailović, Beckei Zsolt, Ljiljana Janković   +7 more
openalex   +1 more source

Farm Animal Welfare and Quality Verification [PDF]

Existing empirical evidence suggests that farm animal welfare may not be a top-of-mind issue for many consumers in North America. Nevertheless, there is pressure from animal welfare groups on food retailers and processors to implement more stringent ...
Hobbs, Jill E., Uzea, Adrian D.
core   +1 more source