Results 71 to 80 of about 744,936 (304)

A plea to implement robustness into a breeding goal: poultry as an example [PDF]

open access: yes, 2008
The combination of breeding for increased production and the intensification of housing conditions have resulted in increased occurrence of behavioral, physiological, and immunological disorders.
Brom, F.W.A.   +3 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Guidance on the assessment criteria for studies evaluating the effectiveness of stunning interventions regarding animal protection at the time of killing

open access: yesEFSA Journal, 2013
This guidance defines the assessment process and the criteria that will be applied by the Animal Health and Welfare Panel to studies on known new or modified legal stunning interventions to determine their suitability for further assessment. The criteria
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

African swine fever

open access: yesEFSA Journal, 2015
Since entering the eastern EU at the start of 2014, African swine fever (ASF) has spread locally in the wild boar population, independently of outbreaks in domestic pigs.
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Blue whales and seismic surveying in Australia [PDF]

open access: yes
Blue whale populations were devastated in the last century by commercial whaling, which reduced blue whales from a quarter of a million to just a few hundred animals. Australian waters are home to both the Antarctic blue whale and a smaller sub- species,
International Fund for Animal Welfare (IFAW)
core  

The use of animal-based health and welfare parameters – what is it all about? [PDF]

open access: yes, 2008
Organic farming is characterized by several goals that are expressed in daily practices and in standards. Some of the important goals for organic production systems are naturalness, harmony on all levels of production, local recycling of resources, and ...
Winckler, Christoph
core  

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Scientific Opinion on the electrical requirements for waterbath stunning equipment applicable for poultry

open access: yesEFSA Journal, 2012
The Commission requested that EFSA review relevant new scientific references on electrical stunning of poultry and to recommend, if necessary, new electrical requirements applicable for waterbath stunning equipment.
EFSA Panel on Animal Health and Welfare (AHAW)
doaj   +1 more source

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