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Regulatory issues for genetically modified animals [PDF]
Frontiers of Agricultural Science and Engineering, 2020 Precision genetics and breeding have the potential to meet the agricultural needs and goals of the world in the 21st century. These needs include increasing the efficiency of production of animals and improving their products with minimal impact on the ...
Perry Bradbury HACKETT
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Preclinical Models of Follicular Cell-Derived Thyroid Cancer: An Overview from Cancer Cell Lines to Mouse Models [PDF]
Endocrinology and Metabolism, 2022 The overall prognosis of thyroid cancer is excellent, but some patients have grossly invasive disease and distant metastases with limited responses to systemic therapies.
Min Ji Jeon, Bryan R. Haugen
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Genetically modified animals for use in biopharmacology: from research to production [PDF]
Research Results in Pharmacology, 2021 Introduction: In this review, the analysis of technologies for obtaining biologically active proteins from various sources is carried out, and the comparative analysis of technologies for creating producers of biologically active proteins is presented ...
Alexey V. Deykin +15 more
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Guidance on the environmental risk assessment of genetically modified animals [PDF]
EFSA Journal, 2013 This document provides guidance for the environmental risk assessment (ERA) of living genetically modified (GM) animals, namely fish, insects and mammals and birds, to be placed on the European Union (EU) market in accordance with Regulation (EC) No 1829/
EFSA Panel on Genetically Modified Organisms (GMO)
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Transgenes of genetically modified animals detected non-invasively via environmental DNA.
PLoS ONE, 2021 We demonstrate that simple, non-invasive environmental DNA (eDNA) methods can detect transgenes of genetically modified (GM) animals from terrestrial and aquatic sources in invertebrate and vertebrate systems.
Charles C Y Xu +5 more
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Challenges in the use of nanostructures as carriers of nucleic acids in clinical practice
Einstein (São Paulo), 2022 The delivery of nucleic acids to cells is considered a crucial step for the success of genetic modifications aimed at therapeutic purposes or production of genetically modified animals.
Carolina Capobiango Romano Quintão +4 more
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Current status of the application of gene editing in pigs
The Journal of Reproduction and Development, 2021 Genetically modified animals, especially rodents, are widely used in biomedical research. However, non-rodent models are required for efficient translational medicine and preclinical studies.
Fuminori TANIHARA +2 more
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sgRNA Knock-in Mouse Provides an Alternative Approach for In Vivo Genetic Modification
Frontiers in Cell and Developmental Biology, 2022 Functional genomics in a mammalian model such as mice is fundamental for understanding human biology. The CRISPR/Cas9 system dramatically changed the tempo of obtaining genetic mouse models due to high efficiency.
Lichen Zhang +25 more
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Use of rodents as models of human diseases
Journal of Pharmacy and Bioallied Sciences, 2014 Advances in molecular biology have significantly increased the understanding of the biology of different diseases. However, these discoveries have not yet been fully translated into improved treatments for patients with diseases such as cancers.
Thierry F Vandamme
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Cutaneous melanoma in genetically modified animals [PDF]
Pigment Cell Research, 2007 AbstractCutaneous melanomas are tumors originating from skin melanocytes which are present in hair follicles, and interfollicular epidermal and dermal layers. Experimental work in model systems involves in silico, in vitro and in vivo analyses. Such models allow to mimick melanocytic aberrations characteristic of melanoma, and to potentially exploit ...
Lionel, Larue, Friedrich, Beermann
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