Results 211 to 220 of about 164,967 (257)

Personalized and genetically engineered animal models for next-generation surgical implant validation. [PDF]

Ann Med Surg (Lond)
Vickram AS, Infant SS, Saravanan A, Mathan MCM, Gulothungan G, Chopra H.   +5 more
europepmc   +1 more source

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Genetically modified animals and immunodeficiency

Current Opinion in Immunology, 1993
Mouse strains with defined genetic defects engineered by the method of targeted gene disruption and homologous recombination have furthered our understanding of immune functions at the single gene level. More importantly, these mutant 'gene knockout' mice are powerful in vivo tools to dissect the complex mechanisms of lymphocyte development and ...
R S, Yeung, J, Penninger, T W, Mak
openaire   +2 more sources

Genetically Modified Animals

2012
AbstractThis article considers the extraordinary ways in which it is now possible to alter animals and to create new life forms by transgenesis and by the creation of hybrids and chimeras. Transgenic animals are created by transferring genes from one species to another.
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Patents for genetically modified animals

Journal of Animal Science, 1993
Should genetically engineered animals be patented? This issue has been one of the most contentious as lawmakers have grappled with how best to protect intellectual property. Since the 1980 case of Diamond v. Chakrabarty, in which the U.S. Supreme Court ruled that a living microorganism is patentable, the U.S.
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Genetically modified animals: ethical issues

Journal of Animal Science, 1993
The method of ethical analysis is reviewed and applied to questions relating to the unintended consequences, ownership, and metaphysical significance of genetically modified animals. The question of how genetics and recombinant DNA discoveries have an impact on human understanding of the moral community and the limits of acceptable action are ...
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Genetically Modified Animals and Pharmacological Research

2010
This chapter reviews the use of genetically modified animals and the increasingly detailed knowledge of the genomes of the domestic species. The different approaches to genetic modification are outlined as are the advantages and disadvantages of the techniques in different species.
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Animal models of arrhythmia: classic electrophysiology to genetically modified large animals

Nature Reviews Cardiology, 2019
Arrhythmias are common and contribute substantially to cardiovascular morbidity and mortality. The underlying pathophysiology of arrhythmias is complex and remains incompletely understood, which explains why mostly only symptomatic therapy is available.
Sebastian Clauss, Christina Bleyer, Dominik Schüttler, Philipp Tomsits, Simone Renner, Nikolai Klymiuk, Reza Wakili, Steffen Massberg, Eckhard Wolf, Stefan Kääb   +9 more
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Genetically modified animals in pharmacological research: future trends

European Journal of Pharmacology, 1999
The recognition of molecular control elements which govern cell and organ function is essential for the development of novel drug therapies and for an understanding of drug actions. Thus, a major interest is focused on methodologies which permit the identification of novel control elements. This is of particular relevance for the identification of drug
U, Rudolph, H, Möhler
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Environmental safety issues for genetically modified animals

Journal of Animal Science, 1993
Organisms modified by the techniques of modern biotechnology may differ significantly from normal organisms or organisms modified by other methods. Before transgenic organisms are introduced into the environment, the potential environmental effects should be assessed.
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