Results 41 to 50 of about 485,436 (276)

Lack of adverse effects in subchronic and chronic toxicity/carcinogenicity studies on the glyphosate-resistant genetically modified maize NK603 in Wistar Han RCC rats

open access: yesArchives of Toxicology, 2019
In 2012, a controversial study on the long-term toxicity of a Roundup herbicide and the glyphosate-tolerant genetically modified (GM) maize NK603 was published.
P. Steinberg   +31 more
semanticscholar   +1 more source

Effects of chronic browsing on life‐history traits of an irruptive large herbivore population

open access: yesPopulation Ecology, EarlyView.
This study aimed to determine the relationship between diet quality, body mass, and size (hind foot length), and female reproduction and sought to identify the mechanism by which high density under severe food limitations is maintained. Our results demonstrated that sika deer introduced to Nakanoshima Island have maintained high densities through high ...
Koichi Kaji   +9 more
wiley   +1 more source

Production of Cloned Pigs Derived from Double Gene Knockout Cells Using CRISPR/Cas9 System and MACS-based Enrichment System

open access: yesJournal of Animal Reproduction and Biotechnology, 2018
Pigs are considered as optimal donor animal for the successful xenotransplantation. To increase the possibility of clinical application, genetic modification to increase compatibility with human is an important and essential process. Genetic modification
Bumrae Cho   +7 more
doaj   +1 more source

piggyBac-Based Non-Viral In Vivo Gene Delivery Useful for Production of Genetically Modified Animals and Organs

open access: yesPharmaceutics, 2020
In vivo gene delivery involves direct injection of nucleic acids (NAs) into tissues, organs, or tail-veins. It has been recognized as a useful tool for evaluating the function of a gene of interest (GOI), creating models for human disease and basic ...
Masahiro Sato   +4 more
doaj   +1 more source

Genetically modified pigs as donors of cells, tissues, and organs for xenotransplantation

open access: yesAnimal Frontiers, 2019
The number of donated human organs and tissues for patients with terminal organ failure falls far short of the need. According to the United Network for Organ Sharing (www.unos.org), more than 113,000 candidates for transplant are currently on the U.S ...
E. Wolf   +3 more
semanticscholar   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

open access: yesFEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali   +3 more
wiley   +1 more source

Are good ideas enough?: The impact of socio-economic and regulatory factors on GMO commercialisation

open access: yesBiological Research, 2013
In recent years scientific literature has seen an increase in publications describing new transgenic applications. Although technically-sound, these promising developments might not necessarily translate into products available to the consumer.
Núria Vàzquez-Salat
doaj   +1 more source

Efficient In Vivo Introduction of Point Mutations Using ssODN and a Co-CRISPR Approach

open access: yesBiological Procedures Online, 2020
Background The generation of point mutations is a major tool for evaluating the roles of specific nucleotides or amino acids within the regulatory or functional landscape. However, examination of these mutations in vivo requires the generation of animals
Tgst Levi   +4 more
doaj   +1 more source

Recent Advances in Genetically Engineered Microorganisms and their Risks: A Review

open access: yesInternational Journal on Food, Agriculture and Natural Resources, 2023
Genetically engineered microorganisms have applications in various domains, such as agriculture, bioscience, healthcare, life sciences, and research. The novel methods of the system Clustered Regularly Interspaced Short Palindromic Repeats associated ...
Jiregna Gari   +2 more
doaj   +1 more source

Guidance on the risk assessment of food and feed from genetically modified animals and on animal health and welfare aspects

open access: yes, 2012
This document provides guidance for the risk assessment of food and feed containing, consisting of or produced from genetically modified (GM) animals, as well as for the health and welfare assessment of these animals, within the framework of Regulation ...
H. Andersson   +19 more
semanticscholar   +1 more source

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