Identification of calpain cleavage sites in the G1 cyclin-dependent kinase inhibitor p19(INK4d) [PDF]
, 2006 Calpains are a large family of Ca2+-dependent cysteine proteases that are ubiquitously distributed across most cell types and vertebrate species. Calpains play a role in cell differentiation, apoptosis, cytoskeletal remodeling, signal transduction and ...
Croall +13 more
core +2 more sources
Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
doaj +1 more source
Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle [PDF]
, 2015 Skeletal muscle is the major site for glucose disposal, the impairment of which closely associates with the glucose intolerance in diabetic patients. Diabetes-related ankyrin repeat protein (DARP/Ankrd23) is a member of muscle ankyrin repeat proteins ...
Yoshiaki Shimoda +10 more
openalex +6 more sources
ConSole: using modularity of contact maps to locate solenoid domains in protein structures. [PDF]
, 2014 BackgroundPeriodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on
Godzik, Adam, Hrabe, Thomas
core +4 more sources
A clinical and experimental study of adult hereditary spherocytosis in the Chinese population
Kaohsiung Journal of Medical Sciences, 2020 Hereditary spherocytosis (HS) is often misdiagnosed due to lack of specific diagnostic methods. Our study summarized clinical characteristics and described the diagnostic workflow for mild and moderate HS in Chinese individuals, using data from 20 adults,
Jun Xue +4 more
doaj +1 more source
Sequence and Structure-Based Analyses of Human Ankyrin Repeats
Molecules, 2022 Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating units.
Broto Chakrabarty, Nita Parekh
doaj +1 more source
Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]
, 2017 The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra +3 more
core +1 more source
Defects in Cytoskeletal Signaling Pathways, Arrhythmia, and Sudden Cardiac Death
Frontiers in Physiology, 2012 Ankyrin polypeptides are cellular adapter proteins that tether integral membrane proteins to the cytoskeleton in a host of human organs. Initially identified as integral components of the cytoskeleton in erythrocytes, a recent explosion in ankyrin ...
Sakima A Smith +3 more
doaj +1 more source
Spherocytosis-Related L1340P Mutation in Ankyrin Affects Its Interactions with Spectrin
Life, 2023 Previously, we reported a new missense mutation in the ANK1 gene that correlated with the hereditary spherocytosis phenotype. This mutation, resulting in L1340P substitution (HGMD CM149731), likely leads to the changes in the conformation of the ankyrin ...
Beata Machnicka +4 more
doaj +1 more source
Tissue-specific Expression of Distinct Spectrin and Ankyrin Transcripts in Erythroid and Nonerythroid Cells [PDF]
, 1985 cDNA probes for three components of the erythroid membrane skeleton, α spectrin, β spectrin, and ankyrin, were obtained by using monospecific antibodies to screen a λgt11 expression vector library containing cDNA prepared from chicken erythroid poly(A)^+
Lazarides, Elias +3 more
core +3 more sources