Results 161 to 170 of about 30,181 (241)
, 2001 Voltage-dependent sodium (Na+) channels are highly concentrated at nodes of Ranvier in myelinated axons and play a key role in promoting rapid and efficient conduction of action potentials by saltatory conduction.
Lustig, M. +15 more
core +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider +4 more
wiley +1 more source
Poultry ScienceIn poultry, Avian Leukosis Virus (ALV) causes high mortality and significant eradication costs, with no effective vaccines, hindering industry development. Improving resistance to ALV-J offers both economic and ecological value.
Hongwei Jie +7 more
doaj +1 more source
Engineering Murine Cross‐Reactivity Into an Affibody to Human Death Receptor 5
Biotechnology and Bioengineering, Volume 123, Issue 7, Page 1783-1798, July 2026.ABSTRACT Interspecies cross‐reactive protein therapeutics that target conserved epitopes across species are critical for translational research. The present study showcases the engineering of an affibody molecule, originally discovered for binding to human death receptor 5 (hDR5) with 94 nM affinity, to simultaneously acquire cross‐reactivity to murine
Tse‐Han Kuo +3 more
wiley +1 more source
An Ankyrin-Based Mechanism for Functional Organization of Dystrophin and Dystroglycan
, 2008 Summaryβ-dystroglycan (DG) and the dystrophin-glycoprotein complex (DGC) are localized at costameres and neuromuscular junctions in the sarcolemma of skeletal muscle.
Ayalon, Gai +7 more
core +1 more source
European Journal of Pain, Volume 30, Issue 6, July 2026.ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian +8 more
wiley +1 more source
Ankyrin-spectrin scaffolds, from blood to brain
, 2006 The initiation and rapid transduction of electrical signals in the nervous system depends on the proper expression of voltage-gated sodium channels in the axon initial segment and nodes of Ranvier. The localization of sodium channel in neurons depends on
Yang, Yang
core
Detection of Nav1.5 and ankyrin-G by immunoblot.
, 2013 Relative expression of Nav1.5 (Panel A) and 190 kD ankyrin-G (Panel B) in control (non-infarcted hearts) and post infarct canine epicardial tissue. Tissues were collected from infarcted hearts (both EBZ and Remote) at post occlusion 24 hr, 48 hr, and 5 ...
Patrick Wright (470353) +5 more
core +1 more source
Defining AV2‐1 as a novel pharmacological probe to target human and rodent TRPV2
British Journal of Pharmacology, Volume 183, Issue 13, Page 3538-3557, July 2026.Abstract Background and Purpose Transient receptor potential vanilloid 2 (TRPV2) is a non‐selective cation channel implicated in immune cell functions. However, progress in understanding TRPV2 has been limited by a lack of potent and selective pharmacological tools, particularly those targeting the human variant. We aimed to identify and characterise a
Andrea Leipe +6 more
wiley +1 more source