Multiple Domains in the Kv7.3 C-Terminus Can Regulate Localization to the Axon Initial Segment
Frontiers in Cellular Neuroscience, 2020 The voltage-gated Kv7.2/Kv7.3 potassium channel is a critical regulator of neuronal excitability. It is strategically positioned at the axon initial segment (AIS) of neurons, where it effectively inhibits repetitive action potential firing.
Louise Leth Hefting +4 more
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Transient receptor potential channel polymorphisms are associated with the somatosensory function in neuropathic pain patients. [PDF]
PLoS ONE, 2011 Transient receptor potential channels are important mediators of thermal and mechanical stimuli and play an important role in neuropathic pain. The contribution of hereditary variants in the genes of transient receptor potential channels to neuropathic ...
Andreas Binder +21 more
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miR-342-5p Decreases Ankyrin G Levels in Alzheimer’s Disease Transgenic Mouse Models
Cell Reports, 2014 MicroRNA alterations and axonopathy have been reported in patients with Alzheimer’s disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1ΔE9, and PS1-M146V transgenic AD mice, and that this upregulation is ...
Xiaqin Sun, Yu Wu, Mingxue Gu, Yan Zhang
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Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. [PDF]
Circ Res, 2014 Rationale: Na v 1.5 ( SCN5A ) is the primary cardiac voltage-gated Na v channel. Na v 1.5 is critical for cardiac excitability and conduction, and human SCN5A
Makara MA +11 more
europepmc +4 more sources
G-quadruplexes are specifically recognized and distinguished by selected designed ankyrin repeat proteins [PDF]
Nucleic Acids Research, 2014 We introduce designed ankyrin repeat binding proteins (DARPins) as a novel class of highly specific and structure-selective DNA-binding proteins, which can be functionally expressed within all cells. Human telomere quadruplex was used as target to select specific binders with ribosome display.
Scholz Oliver +2 more
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Pathophysiological Roles of Abnormal Axon Initial Segments in Neurodevelopmental Disorders
Cells, 2021 The 20–60 μm axon initial segment (AIS) is proximally located at the interface between the axon and cell body. AIS has characteristic molecular and structural properties regulated by the crucial protein, ankyrin-G.
Masashi Fujitani +2 more
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, 2014 Beta III spectrin is present throughout the elaborate dendritic tree of cerebellar Purkinje cells and is required for normal neuronal morphology and cell survival.
Perkins, Emma M. +6 more
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Cytoskeletal regulation of ENaC: the role of ankyrin G (892.28)
The FASEB Journal, 2014 The epithelial sodium channel (ENaC) is a major determinant of sodium (Na+) and water balance in the kidney. The hormone aldosterone increases ENaC subunit translation and modifies expression of key regulators that alter ENaC function and membrane density.
Christine Klemens +3 more
openaire +1 more source
Neural Regeneration Research, 2021 The axon initial segment (AIS) region is crucial for action potential initiation due to the presence of high-density AIS protein voltage-gated sodium channels (Nav).
Piyush Bhardwaj +2 more
doaj +1 more source
Probing the druggability of the Notch1 ankyrin domain using a fragment-based approach
, 2011 Notch signalling is a highly conserved pathway that is important in the developmental processes that control cell differentiation and cell fates. This canonical pathway involves binding of a transmembrane ligand in one cell to the extraceullular domain ...
core +1 more source