Results 41 to 50 of about 30,181 (241)

Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses. [PDF]

Neuron, 2014
SummaryRecent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been associated with bipolar disorder, schizophrenia, and autism.
Smith KR, Kopeikina KJ, Fawcett-Patel JM, Leaderbrand K, Gao R, Schürmann B, Myczek K, Radulovic J, Swanson GT, Penzes P.   +9 more
europepmc   +2 more sources

Venlafaxine stabilizes axons of the neurons in depression model mice [PDF]

Jichu yixue yu linchuang
Objective To investigate whether the effects of venlafaxine on major depression disorder is associated with ankyrin G. Methods Breed Synapsin-Cre1 and Ankyrin3-floxed mice (Ank3 cKO mice). Ank3 cKO mice and wild type mice were randomly divided into model
SUI Jiaping, WEI Hui
doaj   +1 more source

Homeostatic regulation of extracellular signal-regulated kinase 1/2 activity and axonal Kv7.3 expression by prolonged blockade of hippocampal neuronal activity

Frontiers in Cellular Neuroscience, 2022
Homeostatic plasticity encompasses the mechanisms by which neurons stabilize their synaptic strength and excitability in response to prolonged and destabilizing changes in their network activity.
Brian C. Baculis, Brian C. Baculis, Harish Kesavan, Amanda C. Weiss, Amanda C. Weiss, Edward H. Kim, Gregory C. Tracy, Wenhao Ouyang, Wenhao Ouyang, Nien-Pei Tsai, Nien-Pei Tsai, Hee Jung Chung, Hee Jung Chung, Hee Jung Chung, Hee Jung Chung   +14 more
doaj   +1 more source

Ankyrins and Spectrins in Cardiovascular Biology and Disease

Frontiers in Physiology, 2017
Ankyrins are adaptor proteins critical for the expression and targeting of cardiac membrane proteins, signaling molecules, and cytoskeletal elements.
Mona M. El Refaey, Mona M. El Refaey, Peter J. Mohler, Peter J. Mohler, Peter J. Mohler   +4 more
doaj   +1 more source

Heparan Sulfates Regulate Axonal Excitability and Context Generalization through Ca²⁺/Calmodulin-Dependent Protein Kinase II

Cells, 2023
Our previous studies demonstrated that enzymatic removal of highly sulfated heparan sulfates with heparinase 1 impaired axonal excitability and reduced expression of ankyrin G at the axon initial segments in the CA1 region of the hippocampus ex vivo ...
Inseon Song, Tatiana Kuznetsova, David Baidoe-Ansah, Hadi Mirzapourdelavar, Oleg Senkov, Hussam Hayani, Andrey Mironov, Rahul Kaushik, Michael Druzin, Staffan Johansson, Alexander Dityatev   +10 more
doaj   +1 more source

Key Role of the Membrane Trafficking of Nav1.5 Channel Protein in Antidepressant-Induced Brugada Syndrome

Frontiers in Physiology, 2018
Anti-depressant treatment has been found to be associated with the development of Brugada syndrome (BrS) through poorly defined mechanisms. Herein, this study aimed to explore the molecular basis for amitriptyline-induced BrS.
Xi Chen, Xi Chen, Chao Zhu, Hao Zhou, Yu Zhang, Zhongqi Cai, Honglin Wu, Xiaomeng Ren, Lei Gao, Jiancheng Zhang, Yang Li   +10 more
doaj   +1 more source

The largest isoform of Ankyrin-G is required for lattice structure of the axon initial segment

Biochemical and Biophysical Research Communications, 2021
Alzheimer's disease (AD) is the most frequent neurodegenerative disease and a common dementia in elderly individuals. Previous studies found a strong correlation between axon initial segment (AIS) defects and AD, but it remains unclear whether AD itself changes the arrangement of AIS components, and the mechanisms by which adaptor proteins and ion ...
Yiming Wang, Meiling Guan, Han Wang, Yu Li, Karl Zhanghao, Peng Xi, Yan Zhang   +6 more
openaire   +2 more sources

SiRNA-mediated ankyrin-G silence modulates the expression of voltage-gated Na channels in murine hippocampal HT22 cells

Acta Epileptologica, 2019
Background Voltage-gated sodium channels are the targets of many commonly used antiepileptic drugs. NaV1.6, encoded by Scn8a, increased in chronic mesial temporal epilepsy animal models and co-localized with Ankyrin-G, encoded by Ank3.
Guanzhong Ni, Xiaoting Hao, Xiaodong Cai, Jiaming Qin, Liemin Zhou, Patrick Kwan, Ziyi Chen   +6 more
doaj   +1 more source

Ankyrin-G Is a Molecular Partner of E-cadherin in Epithelial Cells and Early Embryos [PDF]

Journal of Biological Chemistry, 2007
E-cadherin is a ubiquitous component of lateral membranes in epithelial tissues and is required to form the first lateral membrane domains in development. Here, we identify ankyrin-G as a molecular partner of E-cadherin and demonstrate that ankyrin-G and beta-2-spectrin are required for accumulation of E-cadherin at the lateral membrane in both ...
Krishnakumar, Kizhatil, Jonathan Q, Davis, Lydia, Davis, Jan, Hoffman, Brigid L M, Hogan, Vann, Bennett   +5 more
openaire   +2 more sources

Interactions Between Ankyrin-G, Plakophilin-2, and Connexin43 at the Cardiac Intercalated Disc [PDF]

Circulation Research, 2011
Rationale: The early description of the intercalated disc defined 3 structures, all of them involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions.
Priscila Y, Sato, Wanda, Coombs, Xianming, Lin, Oxana, Nekrasova, Kathleen J, Green, Lori L, Isom, Steven M, Taffet, Mario, Delmar   +7 more
openaire   +2 more sources