Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. [PDF]
J Biol Chem, 2012 Ankyrin-G (AnkG) coordinates protein composition of diverse membrane domains, including epithelial lateral membranes and neuronal axon initial segments. However, how AnkG itself localizes to these membrane domains is not understood. We report that AnkG remains on the plasma membrane in Madin-Darby canine kidney (MDCK) cells grown in low calcium ...
He M, Jenkins P, Bennett V.
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Neurodevelopmental mutation of giant ankyrin-G disrupts a core mechanism for axon initial segment assembly [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2019 Rui Yang, Haidun Yan, Sara Alvarez
exaly +2 more sources
Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters
Channels, 2022 The ankyrin proteins (Ankyrin-R, Ankyrin-B, and Ankyrin-G) are a family of scaffolding, or membrane adaptor proteins necessary for the regulation and targeting of several types of ion channels and membrane transporters throughout the body.
Sharon R. Stevens, Matthew N. Rasband
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Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure. [PDF]
JACC Basic Transl Sci, 2018 Ankyrin polypeptides are intracellular proteins responsible for targeting cardiac membrane proteins. Here, the authors demonstrate that ankyrin-G plays an unexpected role in normal compensatory physiological remodeling in response to myocardial stress and aging; the authors implicate disruption of ankyrin-G in human heart failure.
Makara MA +13 more
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Crystal structure of human Ankyrin G death domain. [PDF]
Proteins, 2014 ABSTRACTAnkyrins (Ank) are a ubiquitously expressed family of multifunctional membrane adapter proteins. Ankyrin G (AnkG) is critical for assembling and maintenance of the axon initial segment. Here we present the 2.1 Å crystal structure of human AnkG death domain (hAnkG‐DD). The core death domain is composed of six α‐helices and three 310‐helices.
Liu Y, Zhang Y, Wang JH.
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Ankyrin-G Heterozygous Knockout Mice Display Increased Sensitivity to Social Defeat Stress. [PDF]
Complex Psychiatry, 2021 The ANK3 locus has been repeatedly found to confer an increased risk for bipolar disorder. ANK3 codes for Ankyrin-G (Ank-G), a scaffold protein concentrated at axon initial segments, nodes of Ranvier, and dendritic spines, where it organizes voltage-gated sodium and potassium channels and cytoskeletal proteins. Mice with homozygous conditional knockout
Cordner ZA +7 more
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Ankyrin-G isoform imbalance and interneuronopathy link epilepsy and bipolar disorder. [PDF]
Mol Psychiatry, 2017 ANK3, encoding the adaptor protein Ankyrin-G (AnkG), has been implicated in bipolar disorder by genome-wide association studies. ANK3 has multiple alternative first exons, and a bipolar disorder-associated ANK3 variant has been shown to reduce the expression of exon 1b.
Lopez AY +9 more
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Exon organization and novel alternative splicing of Ank3 in mouse heart. [PDF]
PLoS ONE, 2015 Ankyrin-G is an adaptor protein that links membrane proteins to the underlying cytoskeletal network. Alternative splicing of the Ank3 gene gives rise to multiple ankyrin-G isoforms in numerous tissues.
Gokay Yamankurt +3 more
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Reframing the axon initial segment: Giant ankyrin-G as a modulator of excitability and plasticity in neurodevelopment. [PDF]
Proc Natl Acad Sci U S ALopez AY, Jenkins PM.
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Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice
, 2023 The axon initial segment (AIS) constitutes not only the site of action potential initiation, but also a hub for activity-dependent modulation of output generation. Recent studies shedding light on AIS function used predominantly post hoc approaches since no robust murine in vivo live reporters exist.
Thome C +20 more
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