Ankyrin-G regulated epithelial phenotype is required for mouse lens morphogenesis and growth. [PDF]
Dev Biol, 2019 Epithelial cell polarity, adhesion, proliferation, differentiation and survival are essential for morphogenesis of various organs and tissues including the ocular lens. The molecular mechanisms regulating the lens epithelial phenotype however, are not well understood.
Rasiah PK, Maddala R, Bennett V, Rao PV.
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Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment. [PDF]
Front Cell Neurosci, 2017 The axon initial segment (AIS) is a specialized neuronal compartment that plays a key role in neuronal development and excitability. It concentrates multiple ion channels and cell adhesion molecules. The anchoring of these AIS membrane components is known to be highly dependent of the scaffold protein ankyrin G (ankG) but whether ankG membrane partners
Leterrier C +5 more
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Restriction of 480/270-kD Ankyrin G to Axon Proximal Segments Requires Multiple Ankyrin G-specific Domains [PDF]
The Journal of Cell Biology, 1998 AnkyrinG (−/−) neurons fail to concentrate voltage-sensitive sodium channels and neurofascin at their axon proximal segments, suggesting that ankyrinG is a key component of a structural pathway involved in assembly of specialized membrane domains at axon proximal segments and possibly nodes of Ranvier (Zhou, D., S. Lambert, D.L. Malen, S. Carpenter, L.
X, Zhang, V, Bennett
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Bilaterian Giant Ankyrins Have a Common Evolutionary Origin and Play a Conserved Role in Patterning the Axon Initial Segment. [PDF]
PLoS Genetics, 2016 In vertebrate neurons, the axon initial segment (AIS) is specialized for action potential initiation. It is organized by a giant 480 Kd variant of ankyrin G (AnkG) that serves as an anchor for ion channels and is required for a plasma membrane diffusion ...
Timothy Jegla +9 more
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Impaired AIS plasticity in ankyrin-G mutant mice alters cortical excitability and behavior. [PDF]
Proc Natl Acad Sci U S AThe developing brain undergoes neuroplasticity driven by learning, experience, and memory formation. The axon initial segment (AIS) is a specialized membrane domain within the proximal axon that initiates action potential. Studies have demonstrated that the AIS exhibits plasticity by altering its length and/or localization to ...
Li M +11 more
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Identification of AnkG107, a Muscle-specific Ankyrin-G Isoform [PDF]
Journal of Biological Chemistry, 2002 We previously showed that alternatively spliced ankyrins-G, the Ank3 gene products, are expressed in skeletal muscle and localize to the postsynaptic folds and to the sarcoplasmic reticulum. Here we report the molecular cloning, tissue expression, and subcellular targeting of Ank(G107), a novel ankyrin-G from rat skeletal muscle.
Gagelin, Claire +8 more
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An ankyrin G-binding motif mediates TRAAK periodic localization at axon initial segments of hippocampal pyramidal neurons. [PDF]
Proc Natl Acad Sci U S AThe axon initial segment (AIS) is a critical compartment in neurons. It converts post-synaptic input into action potentials that subsequently trigger information transfer to target neurons.
Luque-Fernández V +6 more
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The ankyrin repeats and DHHC S-acyl transferase domain of AKR1 act independently to regulate switching from vegetative to mating states in yeast. [PDF]
PLoS ONE, 2011 Signal transduction from G-protein coupled receptors to MAPK cascades through heterotrimeric G-proteins has been described for many eukaryotic systems.
Piers A Hemsley, Claire S Grierson
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Isoforms of Spectrin and Ankyrin Reflect the Functional Topography of the Mouse Kidney. [PDF]
PLoS ONE, 2016 The kidney displays specialized regions devoted to filtration, selective reabsorption, and electrolyte and metabolite trafficking. The polarized membrane pumps, channels, and transporters responsible for these functions have been exhaustively studied ...
Michael C Stankewich +4 more
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Ankyrin G Expression Regulates Apical Delivery of the Epithelial Sodium Channel (ENaC). [PDF]
J Biol Chem, 2017 Research paper describing the interaction of the epithelial sodium channel (ENaC) and the scaffolding protein ankyrin G (AnkG) in renal collecting duct ...
Klemens CA +4 more
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