Results 11 to 20 of about 30,181 (241)
Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. [PDF]
Mol Psychiatry, 2020 GABAergic circuits are critical for the synchronization and higher order function of brain networks. Defects in this circuitry are linked to neuropsychiatric diseases, including bipolar disorder, schizophrenia, and autism.
Nelson AD +15 more
europepmc +6 more sources
NF-κB regulates neuronal ankyrin-G via a negative feedback loop. [PDF]
Sci Rep, 2017 The axon initial segment (AIS) is a neuronal compartment defined by ankyrin-G expression. We here demonstrate that the IKK-complex co-localizes and interacts with the cytoskeletal anchor protein ankyrin-G in immunoprecipitation and proximity-ligation ...
König HG +6 more
europepmc +5 more sources
Ankyrin-G regulates neurogenesis and Wnt signaling by altering the subcellular localization of β-catenin. [PDF]
Mol Psychiatry, 2015 Ankyrin-G is a scaffolding protein required for the formation of the axon initial segment in neurons. Recent genome-wide association studies and whole-exome sequencing have identified ANK3, the gene coding for ankyrin-G, to be a risk gene for multiple ...
Durak O +6 more
europepmc +8 more sources
Dynamic spectrin/ankyrin-G microdomains promote lateral membrane assembly by opposing endocytosis [PDF]
Science Advances, 2015 Locally dynamic micrometer-scale domains based on spectrin and ankyrin-G determine membrane identity by preventing endocytosis.
Paul M Jenkins, Vann Bennett
exaly +4 more sources
eLife, 2017 Ankyrins together with their spectrin partners are the master organizers of micron-scale membrane domains in diverse tissues. The 24 ankyrin (ANK) repeats of ankyrins bind to numerous membrane proteins, linking them to spectrin-based cytoskeletons at ...
Keyu Chen +4 more
doaj +2 more sources
Roles and mechanisms of ankyrin-G in neuropsychiatric disorders. [PDF]
Exp Mol Med, 2022 AbstractAnkyrin proteins act as molecular scaffolds and play an essential role in regulating cellular functions. Recent evidence has implicated the ANK3 gene, encoding ankyrin-G, in bipolar disorder (BD), schizophrenia (SZ), and autism spectrum disorder (ASD).
Yoon S, Piguel NH, Penzes P.
europepmc +3 more sources
Giant ankyrin-G regulates cardiac function. [PDF]
J Biol Chem, 2021 Cardiovascular disease (CVD) remains the most common cause of adult morbidity and mortality in developed nations. As a result, predisposition for CVD is increasingly important to understand. Ankyrins are intracellular proteins required for the maintenance of membrane domains.
Cavus O +15 more
europepmc +4 more sources
An unfolding role for ankyrin-G at the axon initial segment. [PDF]
Proc Natl Acad Sci U S A, 2019 The ability of neurons to integrate convergent inputs and generate action potentials, the physiological currency of activity, relies on the axon initial segment (AIS). This specialized segment of the proximal axon is the site of electrogenesis in neurons (1), reflecting its striking enrichment in voltage-gated sodium channels (NaV).
Salzer JL.
europepmc +4 more sources
Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. [PDF]
J Biol Chem, 2016 Dynamic regulation of endothelial cell adhesion is central to vascular development and maintenance. Furthermore, altered endothelial adhesion is implicated in numerous diseases. Therefore, normal vascular patterning and maintenance require tight regulation of endothelial cell adhesion dynamics. However, the mechanisms that control junctional plasticity
Cadwell CM +3 more
europepmc +4 more sources
Ankyrin G organizes membrane components to promote coupling of cell mechanics and glucose uptake. [PDF]
Nat Cell Biol, 2021 The response of cells to forces is critical for their function and occurs via rearrangement of the actin cytoskeleton1. Cytoskeletal remodelling is energetically costly2,3, yet how cells signal for nutrient uptake remains undefined. Here we present evidence that force transmission increases glucose uptake by stimulating glucose transporter 1 (GLUT1 ...
Salvi AM +4 more
europepmc +4 more sources