Structural and Energetic Characterization of the Ankyrin Repeat Protein Family. [PDF]
PLoS Computational Biology, 2015 Ankyrin repeat containing proteins are one of the most abundant solenoid folds. Usually implicated in specific protein-protein interactions, these proteins are readily amenable for design, with promising biotechnological and biomedical applications ...
R Gonzalo Parra +3 more
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Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors [PDF]
Viruses, 2022 Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold. Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a ...
Marcel Walser +2 more
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Diabetes-Related Ankyrin Repeat Protein (DARP/Ankrd23) Modifies Glucose Homeostasis by Modulating AMPK Activity in Skeletal Muscle. [PDF]
, 2015 Skeletal muscle is the major site for glucose disposal, the impairment of which closely associates with the glucose intolerance in diabetic patients. Diabetes-related ankyrin repeat protein (DARP/Ankrd23) is a member of muscle ankyrin repeat proteins ...
Chen, Ju +10 more
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Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat [PDF]
Nature Communications, 2023 Wheat (Triticum aestivum L.) is a major staple food for more than one-third of the world’s population. Tiller number is an important agronomic trait in wheat, but only few related genes have been cloned.
Chunhao Dong +19 more
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Research progress of ankyrin repeat domain 1 protein: an updated review [PDF]
Cellular & Molecular Biology LettersAnkyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases.
Xusan Xu +6 more
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The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation [PDF]
Cell Death DiscoveryAnkyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein–protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved
Meijuan Wu +7 more
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Discrete kinetic models from funneled energy landscape simulations. [PDF]
PLoS ONE, 2012 A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK).
Nicholas P Schafer +5 more
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Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask [PDF]
Cell Communication and SignalingBackground Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar +4 more
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Engineering bispecific HER2xVEGF designed ankyrin repeat proteins for targeted nanobiotechnology applications [PDF]
Journal of NanobiotechnologyBackground Targeting both tumor cell surface receptors and soluble pro-angiogenic factors is a promising strategy to improve cancer treatment specificity and reduce therapy resistance.
Feng Chen, Michelle S. Bradbury
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The Rickettsial Ankyrin Repeat Protein 2 Is a Type IV Secreted Effector That Associates with the Endoplasmic Reticulum [PDF]
mBio, 2018 Strains of Rickettsia rickettsii, the tick-borne agent of Rocky Mountain spotted fever, vary considerably in virulence. Genomic comparisons of R. rickettsii strains have identified a relatively small number of genes divergent in an avirulent strain ...
Stephanie S. Lehman +10 more
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