Ankyrin repeats in context with human population variation. [PDF]
PLoS Computational Biology, 2021 Ankyrin protein repeats bind to a wide range of substrates and are one of the most common protein motifs in nature. Here, we collate a high-quality alignment of 7,407 ankyrin repeats and examine for the first time, the distribution of human population ...
Javier S Utgés +4 more
doaj +5 more sources
Structural and Energetic Characterization of the Ankyrin Repeat Protein Family. [PDF]
PLoS Computational Biology, 2015 Ankyrin repeat containing proteins are one of the most abundant solenoid folds. Usually implicated in specific protein-protein interactions, these proteins are readily amenable for design, with promising biotechnological and biomedical applications ...
R Gonzalo Parra +3 more
doaj +4 more sources
Sequence and Structure-Based Analyses of Human Ankyrin Repeats [PDF]
Molecules, 2022 Ankyrin is one of the most abundant protein repeat families found across all forms of life. It is found in a variety of multi-domain and single domain proteins in humans with diverse number of repeating units.
Broto Chakrabarty, Nita Parekh
doaj +3 more sources
Designed Ankyrin Repeat Proteins: A New Class of Viral Entry Inhibitors [PDF]
Viruses, 2022 Designed ankyrin repeat proteins (DARPins) are engineered proteins comprising consensus designed ankyrin repeats as scaffold. Tightly packed repeats form a continuous hydrophobic core and a large groove-like solvent-accessible surface that creates a ...
Marcel Walser +2 more
doaj +2 more sources
Tiller Number1 encodes an ankyrin repeat protein that controls tillering in bread wheat [PDF]
Nature Communications, 2023 Wheat (Triticum aestivum L.) is a major staple food for more than one-third of the world’s population. Tiller number is an important agronomic trait in wheat, but only few related genes have been cloned.
Chunhao Dong +19 more
doaj +2 more sources
Research progress of ankyrin repeat domain 1 protein: an updated review [PDF]
Cellular & Molecular Biology LettersAnkyrin repeat domain 1 (Ankrd1) is an acute response protein that belongs to the muscle ankyrin repeat protein (MARP) family. Accumulating evidence has revealed that Ankrd1 plays a crucial role in a wide range of biological processes and diseases.
Xusan Xu +6 more
doaj +2 more sources
The role of ankyrin repeat-containing proteins in epigenetic and transcriptional regulation [PDF]
Cell Death DiscoveryAnkyrin repeat (AR) motif is one of the most abundant repeat motifs found in eukaryotic proteins. It functions in mediating protein–protein interactions and regulating numerous biological functions. Interestingly, some AR-containing proteins are involved
Meijuan Wu +7 more
doaj +2 more sources
An ankyrin repeat chaperone targets toxic oligomers during amyloidogenesis. [PDF]
Protein Sci, 2023 AbstractNumerous age‐linked diseases are rooted in protein misfolding; this has motivated the development of small molecules and therapeutic antibodies that target the aggregation of disease‐linked proteins. Here we explore another approach: molecular chaperones with engineerable protein scaffolds such as the ankyrin repeat domain (ARD).
Gupta A, Lu C, Wang F, Chou TF, Shan SO.
europepmc +3 more sources
Discrete kinetic models from funneled energy landscape simulations. [PDF]
PLoS ONE, 2012 A general method for facilitating the interpretation of computer simulations of protein folding with minimally frustrated energy landscapes is detailed and applied to a designed ankyrin repeat protein (4ANK).
Nicholas P Schafer +5 more
doaj +6 more sources
Regulation of Notch signaling by multiple Ankyrin repeat containing protein Mask [PDF]
Cell Communication and SignalingBackground Notch pathway is an evolutionarily conserved, highly pleiotropic signaling system that governs diverse developmental processes. Its diverse functions are attributed to the intricate regulatory mechanisms that finely tune the pathway.
Bappi Sarkar +4 more
doaj +2 more sources