Results 21 to 30 of about 41,338 (239)
Nanospring behaviour of ankyrin repeats [PDF]
Nature, 2006 Ankyrin repeats are an amino-acid motif believed to function in protein recognition; they are present in tandem copies in diverse proteins in nearly all phyla. Ankyrin repeats contain antiparallel alpha-helices that can stack to form a superhelical spiral. Visual inspection of the extrapolated structure of 24 ankyrin-R repeats indicates the possibility
Gwangrog, Lee +5 more
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Multifunctional protein: cardiac ankyrin repeat protein [PDF]
Journal of Zhejiang University-SCIENCE B, 2016 Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now.
Na, Zhang, Xiao-Jie, Xie, Jian-An, Wang
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Mechanical Unfolding of an Ankyrin Repeat Protein [PDF]
Biophysical Journal, 2010 Ankryin repeat proteins comprise tandem arrays of a 33-residue, predominantly alpha-helical motif that stacks roughly linearly to produce elongated and superhelical structures. They function as scaffolds mediating a diverse range of protein-protein interactions, and some have been proposed to play a role in mechanical signal transduction processes in ...
Serquera D. +5 more
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Communications Biology, 2023 Ankyrin repeat and LEM-domain containing protein 1 (ANKLE1) cleaves the mitochondrial genome during erythropoiesis and ectopic expression of ANKLE1 promotes genome instability and apoptotic resistance, which contributes to breast cancer risk.
Piotr Przanowski +2 more
doaj +1 more source
Identifying tandem Ankyrin repeats in protein structures [PDF]
BMC Bioinformatics, 2014 Tandem repetition of structural motifs in proteins is frequently observed across all forms of life. Topology of repeating unit and its frequency of occurrence are associated to a wide range of structural and functional roles in diverse proteins, and defects in repeat proteins have been associated with a number of diseases.
Chakrabarty, Broto, Parekh, Nita
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ConSole: using modularity of contact maps to locate solenoid domains in protein structures. [PDF]
, 2014 BackgroundPeriodic proteins, characterized by the presence of multiple repeats of short motifs, form an interesting and seldom-studied group. Due to often extreme divergence in sequence, detection and analysis of such motifs is performed more reliably on
Godzik, Adam, Hrabe, Thomas
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Dynamic scaffolds for neuronal signaling: in silico analysis of the TANC protein family [PDF]
, 2017 The emergence of genes implicated across multiple comorbid neurologic disorders allows to identify shared underlying molecular pathways. Recently, investigation of patients with diverse neurologic disorders found TANC1 and TANC2 as possible candidate ...
Gasparini, Alessandra +3 more
core +1 more source
Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization
Nature Communications, 2021 The V3-crown of the HIV-1 envelope protein largely elicits non-neutralizing antibodies. Here, the authors show that the V3-crown can be targeted by broadly neutralizing designed ankyrin repeat proteins recognizing two conformations one of which resembles
Nikolas Friedrich +24 more
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Resolving the fine structure in the energy landscapes of repeat proteins
QRB Discovery, 2022 Ankyrin (ANK) repeat proteins are coded by tandem occurrences of patterns with around 33 amino acids. They often mediate protein–protein interactions in a diversity of biological systems.
Murilo N. Sanches +6 more
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Detecting Repetitions and Periodicities in Proteins by Tiling the Structural Space [PDF]
, 2013 The notion of energy landscapes provides conceptual tools for understanding the complexities of protein folding and function. Energy Landscape Theory indicates that it is much easier to find sequences that satisfy the "Principle of Minimal Frustration ...
Espada, Rocío +4 more
core +2 more sources