Results 21 to 30 of about 42,872 (270)

Folding and Stability of Ankyrin Repeats Control Biological Protein Function

Biomolecules, 2021
Ankyrin repeat proteins are found in all three kingdoms of life. Fundamentally, these proteins are involved in protein-protein interaction in order to activate or suppress biological processes. The basic architecture of these proteins comprises repeating
Amit Kumar, Jochen Balbach
doaj   +1 more source

The diversity and evolution of Wolbachia ankyrin repeat domain genes. [PDF]

PLoS ONE, 2013
Ankyrin repeat domain-encoding genes are common in the eukaryotic and viral domains of life, but they are rare in bacteria, the exception being a few obligate or facultative intracellular Proteobacteria species.
Stefanos Siozios, Panagiotis Ioannidis, Lisa Klasson, Siv G E Andersson, Henk R Braig, Kostas Bourtzis   +5 more
doaj   +1 more source

An N-terminal and ankyrin repeat domain interactome of Shank3 identifies the protein complex with the splicing regulator Nono in mice. [PDF]

Genes Cells
Okuzono S, Fujii F, Setoyama D, Taira R, Shinmyo Y, Kato H, Masuda K, Yonemoto K, Akamine S, Matsushita Y, Motomura Y, Sakurai T, Kawasaki H, Han K, Kato TA, Torisu H, Kang D, Nakabeppu Y, Ohga S, Sakai Y.   +19 more
europepmc   +3 more sources

StaRProtein, a web server for prediction of the stability of repeat proteins. [PDF]

PLoS ONE, 2015
Repeat proteins have become increasingly important due to their capability to bind to almost any proteins and the potential as alternative therapy to monoclonal antibodies. In the past decade repeat proteins have been designed to mediate specific protein-
Yongtao Xu, Xu Zhou, Meilan Huang
doaj   +1 more source

The push-to-open mechanism of the tethered mechanosensitive ion channel NompC

eLife, 2021
NompC is a mechanosensitive ion channel responsible for the sensation of touch and balance in Drosophila melanogaster. Based on a resolved cryo-EM structure, we performed all-atom molecular dynamics simulations and electrophysiological experiments to ...
Yang Wang, Yifeng Guo, Guanluan Li, Chunhong Liu, Lei Wang, Aihua Zhang, Zhiqiang Yan, Chen Song   +7 more
doaj   +1 more source

Mechanical Anisotropy of Ankyrin Repeats [PDF]

Biophysical Journal, 2012
Red blood cells are frequently deformed and their cytoskeletal proteins such as spectrin and ankyrin-R are repeatedly subjected to mechanical forces. While the mechanics of spectrin was thoroughly investigated in vitro and in vivo, little is known about the mechanical behavior of ankyrin-R.
Lee, W, Zeng, X, Rotolo, K, Yang, M, Schofield, C, Bennett, V, Yang, W, Marszalek, P   +7 more
openaire   +3 more sources

Determination of Ankyrin Repeats Domain (ANK) of RNASE L Gene in Hepatitis C Patients and its effects on Viral Load

Pakistan Journal of Medicine and Dentistry, 2020
Background: Hepatitis C virus (HCV) is one of the major global causes of death. Different types of gene are involved as Ankyrin repeat domains of RNASE L gene.
Anum Liaquat Ali, Syed M. Zahid Azam, Sikandar Ali, Saba Kamil   +3 more
doaj   +1 more source

Multifunctional protein: cardiac ankyrin repeat protein [PDF]

Journal of Zhejiang University-SCIENCE B, 2016
Cardiac ankyrin repeat protein (CARP) not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now.
Na, Zhang, Xiao-Jie, Xie, Jian-An, Wang
openaire   +2 more sources

Mechanical Unfolding of an Ankyrin Repeat Protein [PDF]

Biophysical Journal, 2010
Ankryin repeat proteins comprise tandem arrays of a 33-residue, predominantly alpha-helical motif that stacks roughly linearly to produce elongated and superhelical structures. They function as scaffolds mediating a diverse range of protein-protein interactions, and some have been proposed to play a role in mechanical signal transduction processes in ...
Serquera D., Lee W., Settanni G., Marszalek P. E., Paci E., Ltzhaki L. S.   +5 more
openaire   +2 more sources

ANKLE1 cleaves mitochondrial DNA and contributes to cancer risk by promoting apoptosis resistance and metabolic dysregulation

Communications Biology, 2023
Ankyrin repeat and LEM-domain containing protein 1 (ANKLE1) cleaves the mitochondrial genome during erythropoiesis and ectopic expression of ANKLE1 promotes genome instability and apoptotic resistance, which contributes to breast cancer risk.
Piotr Przanowski, Róża K. Przanowska, Michael J. Guertin   +2 more
doaj   +1 more source