Results 91 to 100 of about 2,806 (200)
Quantitative linkage of physiology and gene expression through empirical model construction: an investigation of diabetes [PDF]
, 2003 A methodology for the construction of predictive empirical models of physiological characteristics from microarray data is presented. The method, applied here to the study of the development of diabetes and insulin resistance, can be further expanded to ...
Alevizos, I. +5 more
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Hippo Pathway Drives Durable Non‐Cell‐Autonomous Ferroptosis Resistance in Lung Cancer
Cancer Science, EarlyView.YAP/TAZ, key effectors in lung cancer progression, paradoxically sensitize tumor cells to ferroptosis. This study reveals that YAP/TAZ‐low cells confer non‐cell‐autonomous, GCH1‐mediated durable ferroptosis resistance to neighboring YAP/TAZ‐high cells via a soluble factor, highlighting a Hippo pathway‐linked mechanism of tumor adaptation and survival ...
Mohamed Fathi Saleh +6 more
wiley +1 more source
, 2016 Darrera actualització: 13 de gener de 2017Pòsters publicats a la revista Journal of cell science, que corresponen a ampliacions d'imatges d'alguns ...
Universitat de Barcelona. CRAI Biblioteca de Biologia
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Loss of Saltation and Presynaptic Action Potential Failure in Demyelinated Axons [PDF]
, 2017 In cortical pyramidal neurons the presynaptic terminals controlling transmitter release are located along unmyelinated axon collaterals, far from the original action potential (AP) initiation site, the axon initial segment (AIS). Once initiated, APs will
Maarten H. P. Kole +2 more
core +2 more sources
Expanding the Genotype and Phenotype Diversity in a Chinese Cohort With TRPV4‐Related Dysplasia
Clinical Genetics, EarlyView.Exploring the genotype and phenotype diversity in a Chinese cohort with TRPV4‐related dysplasia. ABSTRACT Dominant mutations in the calcium permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically result in skeletal dysplasia or peripheral neuromuscular disease.
Lina Dong +8 more
wiley +1 more source
Cell Proliferation, EarlyView.Decreased sialic acid increases the adhesion of RBC membranes to immunoglobulins leading to an increased erythrocyte sedimentation rate (ESR). The increase in reactive oxygen species (ROS) damages the sialic acid glycosyl chains on the surface of RBC membrane proteins, causing the membrane proteins to be overexposed to the plasma environment due to the
Sicheng Bian +16 more
wiley +1 more source
Ankyrin-B Is Required for Intracellular Sorting of Structurally Diverse Ca2+ Homeostasis Proteins [PDF]
, 1999 This report describes a congenital myopathy and major loss of thymic lymphocytes in ankyrin-B (−/−) mice as well as dramatic alterations in intracellular localization of key components of the Ca2+ homeostasis machinery in ankyrin-B (−/−) striated muscle ...
Bennett, Vann +4 more
core +3 more sources
EHD4 and ASAP2 are critical negative regulators of the claudin‐5‐based endothelial barrier
The FEBS Journal, EarlyView.Cell‐surface CLDN‐5 protein levels can be evaluated using a probe that can bind to the extracellular domains of CLDN‐5. A probe derived from Clostridium perfringens enterotoxin allows us to isolate cells with high CLDN‐5 protein levels from a knockout cell library.
Yosuke Hashimoto +8 more
wiley +1 more source
Exploring Symbioses by Single-Cell Genomics [PDF]
, 2012 Single-cell genomics has advanced the field of microbiology from the analysis of microbial metagenomes where information is “drowning in a sea of sequences,” to recognizing each microbial cell as a separate and unique entity. Single-cell genomics employs
Bayer, Kristina +3 more
core +1 more source