Results 121 to 130 of about 2,806 (200)
Advanced Science, Volume 13, Issue 7, 3 February 2026.This study identifies CD74⁺ macrophages as key drivers of synovial inflammation in osteoarthritis (OA). The flavonoid luteolin is predicted to inhibit this pathway by blocking Nuclear Factor Kappa‐light‐chain‐enhancer of Activated B cells (NF‐κB) signaling. To enhance delivery, a targeted nanoplatform (MDSPL) is developed.
Rui Peng +15 more
wiley +1 more source
Single‐cell analysis reveals neuroprotective histone deacetylase inhibitor pathways
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract INTRODUCTION Alzheimer's disease (AD) involves β‐amyloid (Aβ) accumulation, tau pathology, and neuroinflammation, driving cognitive decline. Despite extensive research, disease‐modifying therapies remain elusive. We integrated single‐cell RNA sequencing (scRNA‐seq), spatial transcriptomics, and in vitro validation to identify repurposable ...
Madeline Peyton +12 more
wiley +1 more source
A Role for AnkyrinG in Maturation and Maintenance of the Nodes of Ranvier. [PDF]
, 2017 Curran, Bridget M. +2 more
core +2 more sources
United European Gastroenterology Journal, Volume 14, Issue 1, February 2026.ABSTRACT Background Microscopic colitis (MC), comprising lymphocytic colitis (LC) and collagenous colitis (CC), is an inflammatory bowel disease with increasing incidence. MC etiopathogenesis remains unknown; however, altered colonic epithelial integrity may underlie uncontrolled luminal antigen passage, triggering immuno‐inflammatory responses ...
Danila Guagnozzi +18 more
wiley +1 more source
Functional Analysis of an Orientia tsutsugamushi Ankyrin Effector Protein in a Model Eukaryote [PDF]
, 2019 Orientia tsutsugamushi is an understudied, gram negative, obligate intracellular bacterium that is transmitted by mites within the genus Leptotrombidium.
Bartlett, Dylan
core
Protein tandem repeats that produce frameshifts can generate new structural states and functions
The FEBS Journal, Volume 293, Issue 3, Page 842-858, February 2026.We explored an alternative protein structure landscape by analyzing amino acid sequences from frameshifted tandem repeats—regions prone to frameshifts. These frameshifts, especially in short repeats, lead to more drastic changes than in non‐repetitive regions, often altering structure, function, localization, and potentially contributing to disease ...
Zarifa Osmanli +8 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT TRPM8 is a cold temperature‐sensitive and non‐selective Ca2+‐channel. Previously we have observed that TRPM8 is endogenously expressed and affects T cell activation process. Now, we report that TRPM8 regulates functions of mitochondria and ER, two important sub‐cellular compartments.
Tusar Kanta Acharya +5 more
wiley +1 more source
Neuropathology and Applied Neurobiology, Volume 52, Issue 1, February 2026.The phenotype of OBSCN variants consists of exercise intolerance ranging from myalgia and cramps to rhabdomyolysis. Symptoms are mainly induced by high‐intensity sports. Molecular analysis showing a deregulation of muscle processes associated with Ca2+ regulation, extrasarcolemmal integrity and autophagy emphasised the critical role of obscurin in ...
Heidrun H. Krämer‐Best +8 more
wiley +1 more source
Transcriptional outputs and condensates – formation and function
New Phytologist, Volume 249, Issue 3, Page 1145-1154, February 2026.Summary The dynamic spatiotemporal organization of macromolecules is key to the proper function of the cell, allowing the exquisite regulation of diverse processes from gene expression to enzymatic function. The formation of biomolecular condensates via phase separation (PS) acts as a general mechanism for selectively concentrating proteins, nucleic ...
Stephanie Hutin +4 more
wiley +1 more source