Results 121 to 130 of about 241,609 (354)

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

Deletion of annexin 2 light chain p11 in nociceptors causes deficits in somatosensory coding and pain behavior

, 2006
The S100 family protein p11 (S100A10, annexin 2 light chain) is involved in the trafficking of the voltage-gated sodium channel Na(V)1.8, TWIK-related acid-sensitive K+ channel (TASK-1), the ligand-gated ion channels acid-sensing ion channel 1a (ASIC1a ...
Foulkes, T, Baker, MD, Matthews, EA, Gerke, V, Lane, T, Wood, JN, Okuse, K, Nassar, MA, Dickenson, AH   +8 more
core  

Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.

, 2009
The glucocorticoid-regulated protein annexin A1 is a potent inhibitor of hormone exocytosis in the neuroendocrine system, acting in a paracrine/juxtacrine manner.
Solito E., McArthur, S, McArthur S., Christian, H, Buckingham J., Yazid S., Buckingham, J.C., Solito, E, Yazid, S., Sirha, R., Christian H., Christian, H.C., McArthur, S., Sirha, R, Yazid, S, Buckingham, J, Sirha R., Solito, E., Flower R., Flower, R, Flower, R.J.   +20 more
core   +1 more source

Absence of annexin I expression in B-cell non-Hodgkin's lymphomas and cell lines

BMC Cancer, 2004
Background Annexin I, one of the 20 members of the annexin family of calcium and phospholipid-binding proteins, has been implicated in diverse biological processes including signal transduction, mediation of apoptosis and immunosuppression.
Gopalakrishnan Velliyur K, Salazar Eric, Vishwanatha Jamboor K   +2 more
doaj   +1 more source

The annexins.

Genome biology, 2004
Annexins are traditionally thought of as calcium-dependent phospholipid-binding proteins, but recent work suggests a more complex set of functions. More than a thousand proteins of the annexin superfamily have been identified in major eukaryotic phyla, but annexins are absent from yeasts and prokaryotes.
Stephen E, Moss, Reg O, Morgan
openaire   +1 more source

Combating VEGFA‐siRNA‐Induced Metabolic Reprogramming via Glucose Utilization Deprivation

Advanced Science, EarlyView.
An ionizable lipid nanoparticle co‐delivers VEGFA siRNA and glucose oxidase to tumors to counteract VEGFA knockdown‐induced, glutamine‐driven metabolic compensation. Enzymatic glucose consumption reverses the adaptive pathways and restores metabolism toward baseline, thereby sensitizing tumors to therapy.
Lulu Zheng, Shuai Guo, Yingjixing Luo, Pengfei Wu, Haiyin Yang, Yingqiu Xie, Yuchuan Fan, Qing Liu, Bo Hu, Jia Huang, Yuanyu Huang   +10 more
wiley   +1 more source

Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton

, 2009
The annexins are a family of Ca(2+)- and phospholipid-binding proteins, which interact with membranes upon increase of [Ca(2+)](i) or during cytoplasmic acidification.
Wood, Peta, Grewal, Thomas, Draeger, Annette, Hostettler, Andrea, Monastyrskaya, Katia, Babiychuk, Eduard B   +5 more
core   +1 more source

Oral Bioinspired Peroxisome‐Engineered Probiotics for Modulating Gut Microbiota Homeostasis and Alleviating Cardiac Chemotherapy Toxicity

Advanced Science, EarlyView.
This study developed an oral bioinspired peroxisome‐engineered probiotic (BPEP) by anchoring lipid‐encapsulated ruthenium nanozymes onto Escherichia coli Nissle 1917, utilizing probiotics to deliver nanozymes to the intestinal barrier for reactive oxygen species/reactive nitrogen species elimination, tight junction restoration, and gut microbiota ...
Shuyu Wang, Xiaowan Fan, Chao Zhang, Shuai Han, Yike Guo, Yuchen Wang, Wei Wang, Junyue Xing, Ying Liu, Wei Jiang, Xiaoying Chen   +10 more
wiley   +1 more source

The immune reaction against allogeneic necrotic cells is reduced in Annexin A5 knock out mice whose macrophages display an anti-inflammatory phenotype

, 2008
Proteins of the annexin family bind to phospholipids in a Ca2+ dependent manner. The exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat-me-signal for macrophages.
Rodel, Franz, Sandra Franz, Sieber, Renate, Poschl, Ernst, Holm Schneider, Udo S. Gaipl, Munoz, Luiz E., Bent Brachvogel, Pausch, Friederike, Brachvogel, Bent, Ernst Poschl, Rainer Fietkau, Franz, Sandra, Herrmann, Martin, Sauer, Rolf, Martin Herrmann, Luis E. Munoz, Renate Sieber, Fietkau, Rainer, Rolf Sauer, Frey, Benjamin, Benjamin Frey, Gaipl, Udo S., Schneider, Holm, Friederike Pausch, Franz Rödel   +25 more
core   +1 more source

Interaction of annexin A6 with alpha actinin in cardiomyocytes

BMC Cell Biology, 2011
Background Annexins are calcium dependent phospholipid binding proteins that are expressed in a wide variety of tissues and implicated in various extra- and intracellular processes.
Park Woo J, Lifirsu Ekaterina, Oh Jae G, Banerjee Priyam, Chander Vivek, Mishra Sumita, Kim Do H, Bandyopadhyay Arun   +7 more
doaj   +1 more source