Results 131 to 140 of about 241,609 (354)

Comprehensive analyses of the annexin gene family in wheat

BMC Genomics, 2016
Annexins are an evolutionarily conserved multigene family of calcium-dependent phospholipid binding proteins that play important roles in stress resistance and plant development.
Lei Xu, Yimiao Tang, Shiqing Gao, Shichao Su, L. Hong, Weiwei Wang, Zhaofeng Fang, Xueyin Li, Jinxiu Ma, W. Quan, Hui Sun, Xia Li, Yong-bo Wang, X. Liao, Jian-gang Gao, Feng-ting Zhang, Lei Li, Changping Zhao   +17 more
semanticscholar   +1 more source

Inhibition of SIRT7 Overcomes Radioresistance in Pancreatic Neuroendocrine Tumors by Reactivating MEN1 Expression

Advanced Science, EarlyView.
Pancreatic neuroendocrine tumors frequently silence MEN1 through epigenetic mechanisms. Here, SIRT7 recruits DNMT1 to the MEN1 promoter, drives hypermethylation, and enhances DNA repair. Inhibiting SIRT7 restores MEN1, reduces MRN complex abundance, impairs double‐strand break repair, and sensitizes PanNET models to radiation, supporting SIRT7 as a ...
Jianyun Jiang, Yan Wang, Yi Qin, Luohai Chen, Xiaowu Xu, Guixiong Fan, Desheng Jing, Miaoyan Wei, Xianjun Yu, Junfeng Xu, Shunrong Ji, Jie Chen   +11 more
wiley   +1 more source

Fluorescent annexin A1 reveals dynamics of ceramide platforms in living cells

, 2008
Upon its genesis during apoptosis, ceramide promotes gross reorganization of the plasma membrane structure involving clustering of signalling molecules and an amplification of vesicle formation, fusion and trafficking.
Katia Monastyrskaya, Draeger, Annette, Eduard B. Babiychuk, Monastyrskaya, Katia, Babiychuk, Eduard B, Annette Draeger   +5 more
core   +1 more source

TSPYL5 Promotes Triple‐Negative Breast Cancer Metastasis by Antagonizing USP10‐Mediated PTEN Stabilization to Unleash a ZEB1‐Dependent EMT Program

Advanced Science, EarlyView.
The hyperactivation of PI3K/AKT signaling in PTEN wild‐type triple‐negative breast cancer represents a clinical paradox. We delineate a novel post‐translational regulatory axis wherein the oncogene TSPYL5 competitively antagonizes the deubiquitinase USP10.
Jiaying Shi, Ming Yi, Shengyu Xie, Zhaokun Wang, Xinyue Zhang, Yangwei Zhang, Rui Tang, Yuan Yang, Yunqiang Liu   +8 more
wiley   +1 more source

Annexin A1 in the brain--undiscovered roles?

, 2008
Annexin A1 (ANXA1) is an endogenous protein known to have potent anti-inflammatory properties in the peripheral system. It has also been detected in the brain, but its function there is still ambiguous.
Solito E., McArthur, S, Gillies, G.E., McArthur S., Christian, H, Buckingham, JC, Egle Solito, Gavins, F.N.E., Buckingham, J.C., Felicity Gavins, Solito, E, Gavins F., Gillies G. E., Christian H., Glenda E. Gillies, Christian, H.C., McArthur, S., Helen Christian, Buckingham J. C., Simon McArthur, Julia C. Buckingham, Solito, E., Gavins, F, Gillies, GE   +23 more
core   +1 more source

Immunogenicity, antibody responses and vaccine efficacy of recombinant annexin B30 against Schistosoma mansoni

, 2020
Aims Schistosomes infect approximately 250 million people worldwide. To date, there is no effective vaccine available for the prevention of schistosome infection in endemic regions.
Chuah, Candy, Leow, Chiuan Yee, Jones, Malcolm, Willis, Charlene, Malcolm Jones, Charlene Willis, Candy Chuah, Chiuan Herng Leow, Chiuan Yee Leow, Leow, Chiuan Herng   +9 more
core   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Nuclear Localization of Annexin A1 Is a Prognostic Factor in Oral Squamous Cell Carcinoma

, 2009
Background and Objectives: To investigate whether annexin A1 (ANXA1) expression is a marker in predicting the prognosis of oral cancer patients . Methods: We immunohistochemically examined the expression of ANXA1 in 66 cases of oral epithelial dysplasia (
LIN, CHIAO-YING;JENG, YUNG-MING;CHOU, HAN-YI;HSU, HEY-CHI;YUAN, RAY-HWANG;CHIANG, CHUN-PIN;KUO, MARK YEN-PING, 林佼穎;鄭永銘;周涵怡;許輝吉;袁瑞晃;江俊斌;郭彥彬   +1 more
core   +1 more source

Semaphorin 3D autocrine signaling mediates the metastatic role of annexin A2 in pancreatic cancer

Science Signaling, 2015
Annexin A2–dependent secretion of semaphorin 3D induces metastasis of pancreatic cancer cells. Semaphorin signals guide metastases Semaphorin signaling directs the migration of developing neurons, as well as new blood vessels. The abundance of semaphorin
K. Foley, A. Rucki, Q. Xiao, Donger Zhou, Ashley Leubner, Guanglan Mo, Jennifer Kleponis, Annie A Wu, Rajni B. Sharma, Qingguang Jiang, R. Anders, C. Iacobuzio-Donahue, K. Hajjar, A. Maitra, E. Jaffee, Lei Zheng   +15 more
semanticscholar   +1 more source

Tailored Porous Bimetallic Nanozyme Platform for Full‐Cycle Therapeutics of Intestinal Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Intestinal ischemia/reperfusion (I/R) injury presents a biphasic pathology: an acute oxidative‐inflammatory phase leading to organ failure, and a recovery phase marked by mucosal dysfunction and bacterial translocation. The developed MPB@TA‐Cu‐Ma nanocomposite functions as a dual‐phase therapeutic platform with significant efficacy. It rapidly
Chenghao Qiu, Wenjing Xian, Mengxue Wang, Guozhi Zhao, Yanhuo Zhang, Zhiyu Zhou, Bo Sheng, Zhuo Zhen, Xie Liu, Shouwen Diao, Mengwei Tu, Chen Qiu, Huixian Wang, Jianbo Zhang, Peng Zhu, Tong Li   +15 more
wiley   +1 more source