Results 21 to 30 of about 169,468 (266)

Overexpression of Cassava MeAnn2 Enhances the Salt and IAA Tolerance of Transgenic Arabidopsis

Plants, 2021
Annexins are a superfamily of soluble calcium-dependent phospholipid-binding proteins that have considerable regulatory effects in plants, especially in response to adversity and stress.
Xuejun Lin, Ruimei Li, Yangjiao Zhou, Fenlian Tang, Yajie Wang, Xiaohua Lu, Shijia Wang, Yuan Yao, Jiao Liu, Xinwen Hu, Jianchun Guo   +10 more
doaj   +1 more source

Annexins in Glaucoma

International Journal of Molecular Sciences, 2018
Glaucoma is one of the leading causes of irreversible visual loss, which has been estimated to affect 3.5% of those over 40 years old and projected to affect a total of 112 million people by 2040. Such a dramatic increase in affected patients demonstrates the need for continual improvement in the way we diagnose and treat this condition.
Timothy E. Yap, Benjamin Michael Davis, Li Guo, Eduardo M. Normando, Maria Francesca Cordeiro   +4 more
openaire   +4 more sources

Impairment of Ceramide-Mediated Endothelial Instant Membrane Resealing During Diabetes Mellitus

Frontiers in Physiology, 2022
Recent studies have indicated that instant cell membrane resealing (ICMR) controls the activation of NOD-like receptor pyrin domain containing 3 (Nlrp3) inflammasomes in endothelial cells, thereby initiating and promoting vascular inflammation.
Yang Chen, Yang Chen, Guangbi Li, Owais M. Bhat, Xiang Li, Yang Zhang, Pin-Lan Li   +6 more
doaj   +1 more source

Proteomic Identification of Markers of Membrane Repair, Regeneration and Fibrosis in the Aged and Dystrophic Diaphragm

Life, 2022
Deficiency in the membrane cytoskeletal protein dystrophin is the underlying cause of the progressive muscle wasting disease named Duchenne muscular dystrophy.
Stephen Gargan, Paul Dowling, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck   +6 more
doaj   +1 more source

Grapevine bZIP transcription factor bZIP45 regulates VvANN1 and confers drought tolerance in Arabidopsis

Frontiers in Plant Science, 2023
Drought is a severe environmental condition that restricts the vegetative growth and reduces the yield of grapevine (Vitis vinifera L.). However, the mechanisms underlying grapevine response and adaptation to drought stress remain unclear. In the present
Shuaike Niu, Shuaike Niu, Xiangyang Gu, Qian Zhang, Xuemin Tian, Zhan Chen, Jingru Liu, Xiaoju Wei, Chengxiang Yan, Ziwen Liu, Xiaoji Wang, Zhengge Zhu   +11 more
doaj   +1 more source

New Therapeutic Strategies in Retinal Vascular Diseases: A Lipid Target, Phosphatidylserine, and Annexin A5—A Future Theranostic Pairing in Ophthalmology

Pharmaceuticals
Despite progress in the management of patients with retinal vascular and degenerative diseases, there is still an unmet clinical need for safe and effective therapeutic options with novel mechanisms of action.
Anna Frostegård, Anders Haegerstrand
doaj   +1 more source

Real-Time Imaging of Retinal Cell Apoptosis by Confocal Scanning Laser Ophthalmoscopy and Its Role in Glaucoma

Frontiers in Neurology, 2018
Glaucoma is one of the leading causes of irreversible blindness in the world. It is characterized by the progressive loss of retinal ganglion cells (RGCs), mainly through the process of apoptosis.
Elizabeth Yang, Elizabeth Yang, Toby S. Al-Mugheiry, Eduardo M. Normando, Eduardo M. Normando, Eduardo M. Normando, Maria F. Cordeiro, Maria F. Cordeiro, Maria F. Cordeiro   +8 more
doaj   +1 more source

Translational implications of targeting annexin A2: From membrane repair to muscular dystrophy, cardiovascular disease and cancer

Clinical and Translational Discovery, 2023
Background Annexin A2 contributes to several key cellular functions and processes, including membrane repair. Effective repair prevents cell death and degeneration, especially in skeletal or cardiac muscle, epithelia, and endothelial cells.
Victor G. Kayejo, Hannah Fellner, Roshan Thapa, Peter A. Keyel   +3 more
doaj   +1 more source

AtCRY2 Negatively Regulates the Functions of AtANN2 and AtANN3 in Drought Tolerance by Affecting Their Subcellular Localization and Transmembrane Ca2+ Flow

Frontiers in Plant Science, 2021
Annexins are a multifunctional class of calcium-binding proteins in plants, and their physiological functions and regulation in response to drought stress remain to be elucidated. Here, we found that AtANN2 and AtANN3 conferred to drought tolerance under
Ting Liu, Ting Liu, Leyan Du, Qiushi Li, Qiushi Li, Jingda Kang, Qi Guo, Qi Guo, Shilin Wang, Shilin Wang   +9 more
doaj   +1 more source

Annexins

Trends in Cell Biology, 1997
Ten years after the discovery of annexins, we are just understanding the functions of these enigmatic proteins, been a frustrating decade for those in this field because appear capable of performing a multitude of function: to the sceptic apparently do nothing in vivo.
openaire   +4 more sources