Results 111 to 120 of about 34,339 (250)
Distinct cellular expression pattern of annexins in Hydra vulgaris. [PDF]
, 1992 The annexins are a structurally related family of Ca2+ and phospholipid binding proteins whose function has not been clearly defined. Further investigations of annexin function may be enhanced by studying simpler organisms that express fewer annexin gene
Bode, HR, Haigler, HT, Schlaepfer, DD
core +2 more sources
Annexin A2 expression and partners during epithelial cell differentiation [PDF]
Biochemistry and Cell Biology, 2019 The members of the annexin family of calcium- and phospholipid-binding proteins participate in different cellular processes. Annexin A2 binds to S100A10, forming a functional heterotetrameric protein that has been involved in many cellular functions, such as exocytosis, endocytosis, cell junction formation, and actin cytoskeleton dynamics.
Zibouche, Malik +2 more
openaire +3 more sources
ChemistryOpen, EarlyView.Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel +5 more
wiley +1 more source
Cobimetinib and trametinib inhibit platelet MEK but do not cause platelet dysfunction [PDF]
, 2018 The MEK inhibitors cobimetinib and trametinib are used in combination with BRAF inhibitors to treat metastatic melanoma but increase rates of hemorrhage relative to BRAF inhibitors alone.
Bye, Alex P. +6 more
core +4 more sources
Pneumococcal surface adhesion A protein (PsaA) interacts with human Annexin A2 on airway epithelial cells [PDF]
, 2021 Yoonsung Hu +9 more
openalex +1 more source
Prenatal Diagnosis, EarlyView.ABSTRACT Objective Amnioinfusions in anhydramnios aim to promote fetal lung development, but currently used fluids (Normal Saline [NS], Lactated Ringer's [LR]) fail to mimic the intrauterine environment and increase reactive oxygen species (ROS). We developed a synthetic amniotic fluid (Amnio‐well, AW) designed to reduce intrauterine ROS.
Braxton Forde +3 more
wiley +1 more source
Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy
PROTEOMICS, EarlyView.ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling +6 more
wiley +1 more source
PAI1 blocks NMDA receptor-mediated effects of tissue-type plasminogen activator on cell signaling and physiology [PDF]
, 2018 The fibrinolysis proteinase tissue-type plasminogen activator (tPA, also known as PLAT) triggers cell signaling and regulates cell physiology. In PC12 cells, Schwann cells and macrophages, the N-methyl-D-aspartate receptor (NMDA-R) mediates tPA signaling.
Azmoon, Pardis +5 more
core +2 more sources
Environmental Toxicology, EarlyView.ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei +6 more
wiley +1 more source
Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification. [PDF]
, 2016 Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice.
Cao, Yan +9 more
core +1 more source