Aging Cell, Volume 25, Issue 4, April 2026.This graphical abstract shows that gut luminal exosomes (LFEs) change with aging, with old mice producing LFEs that disrupt gut barrier integrity, alter microbiome composition, and promote insulin resistance. In contrast, LFEs from young mice improve gut barrier function and metabolic health, and transferring these LFEs can partially reverse age ...
Abdelnaby Khalyfa +3 more
wiley +1 more source
Tear proteome analysis in ocular surface diseases using label-free LC-MS/MS and multiplexedmicroarray biomarker validation [PDF]
, 2017 We analyzed the tear film proteome of patients with dry eye (DE), meibomian gland dysfunction (MGD), and normal volunteers (CT). Tear samples were collected from 70 individuals.
Acera, Arantxa +11 more
core +3 more sources
A Novel Dysferlin‐Binding Kinase CK2α Promotes Plasma Membrane Repair in Dysferlinopathy
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.When the cell membrane is injured, extracellular calcium enters the cell, triggering the accumulation of dysferlin at the lesion site. In the presence of dysferlin, CK2 is efficiently recruited to the damaged membrane and maintains its kinase activity through interaction with dysferlin.
Naoko Nakamura +27 more
wiley +1 more source
Traumatic Brain Injury Induces Genome-Wide Transcriptomic, Methylomic, and Network Perturbations in Brain and Blood Predicting Neurological Disorders. [PDF]
, 2017 The complexity of the traumatic brain injury (TBI) pathology, particularly concussive injury, is a serious obstacle for diagnosis, treatment, and long-term prognosis. Here we utilize modern systems biology in a rodent model of concussive injury to gain a
Agrawal, Rahul +5 more
core +2 more sources
Egyptian Liver Journal, 2019 Background Liver cancer is the fifth most common cancer and the second most frequent cause of cancer-related death globally. Early stages of hepatocellular carcinoma (0&A) can be treated with curative procedures.
Abd El-Fattah F. Hanno +4 more
doaj +1 more source
Lipopolysaccharide as trigger of platelet aggregation via eicosanoid over-production [PDF]
, 2017 The effect of lipopolysaccharide (LPS) on platelet aggregation is still controversial. We performed in vitro and ex vivo studies in controls and in patients with community-acquired pneumonia (CAP) to assess the effect of LPS on platelet activation (PA ...
Camilla Calvieri +9 more
core +1 more source
Regulation of Cytosolic Phospholipase A2 Phosphorylation by Proteolytic Cleavage of Annexin A1 in Activated Mast Cells [PDF]
, 2012 Joon Hyun Kwon +4 more
openalex +1 more source
International Journal of Molecular Medicine, 2018 Biliary atresia (BA) is the most common cause of chronic cholestasis in children. The long non‑coding RNA (lncRNA) Annexin A2 pseudogene 3 (ANXA2P3) and Annexin A2 (ANXA2) have been suggested to serve pivotal roles in BA; however, the clinical significance and biological roles of ANXA2P3 and ANXA2 in BA remain to be elucidated.
Nuerzhati, Yeletai +3 more
openaire +3 more sources
The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation [PDF]
, 2016 Xiaowei Wang +15 more
openalex +1 more source
The S100A10-annexin A2 complex provides a novel asymmetric platform for membrane repair. [PDF]
, 2011 Atoosa Rezvanpour +2 more
openalex +1 more source