Results 61 to 70 of about 6,682 (198)

Fusogenic Activity of Annexins A1 and A5 [PDF]

Biophysical Journal, 2011
Annexins are a family of proteins that bind to anionic phospholipids in a calcium-dependent manner and have been implicated in a number of cell biological processes including intracellular fusion. Recently we found that extracellular annexins (A1 and A5) play important roles in myoblast fusion.
Yang, Sung-Tae, Leikina, Eugenia, Melikov, Kamran, Michael, Kozlov M., Chernomordik, Leonid V.   +4 more
openaire   +1 more source

ANTICOAGULANT PROPERTIES OF RECOMBINANT ANNEXIN А5 [PDF]

Biotechnologia Acta
Aim: Because of its involvement in membrane properties, annexin A5 has a significant impact on membrane-dependent processes within hemostasis, including the initiation of the coagulation cascade, the activation of factor X and prothrombin, and the ...
. O. SAVCHENKO, A. O. PAVLENKO1, A. A. SIROMOLOT   +2 more
doaj   +1 more source

Suppressive effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques of apoE-/- mice: molecular imaging with 14C-FDG and 99mTc-annexin A5.

PLoS ONE, 2014
ObjectivesTo investigate the effects of irbesartan on inflammation and apoptosis in atherosclerotic plaques by histochemical examination and molecular imaging using (14)C-FDG and (99m)Tc-annexin A5.BackgroundIrbesartan has a peroxisome proliferator ...
Yan Zhao, Ayahisa Watanabe, Songji Zhao, Tatsuo Kobayashi, Keita Fukao, Yoshikazu Tanaka, Toru Nakano, Tetsuya Yoshida, Hiroshi Takemoto, Nagara Tamaki, Yuji Kuge   +10 more
doaj   +1 more source

Dual‐Responsive Dynamic Covalent Bond‐Based Assembly of Lipid‐Nanozyme Systems via Multi‐Target Synergy and Efficient Target Enrichment for Ischemic Stroke Therapy

Advanced Science, EarlyView.
This system adopts a biomimetic phospholipid structure, covalently binding iNOS inhibitors, neuroprotective agent PCA and vitamin E derivatives through pH/ROS dual‐responsive bonds, and assembles them with Prussian blue nanozyme to form PBB@AHA. It can efficiently penetrate the blood‐brain barrier and simultaneously release multiple active components ...
Mengcheng Guo, Qingran Guan, Guanyu Qiao, Lixue Zhang, Man Liu, Zhen Li, Qingbiao Yang, Meili Shen, Linlin Liu, Yapeng Li   +9 more
wiley   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Annexin A5 confers neuroprotection in ischemic stroke: insights from in vitro and in vivo models

Medicine Plus
Ischemic stroke remains a leading cause of neurological disability worldwide. Effective therapeutic interventions for stroke treatment are still critically needed. Annexin A5, a calcium-dependent phospholipid-binding protein, has been reported to possess
Qi Liu, Jiaqi Guo, Jiachen He, Zhanwei Zhu, Jingbei Liu, Di Wu   +5 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Plasma annexin A5 level relates inversely to the severity of coronary stenosis.

, 2007
Contains fulltext : 51934.pdf (Publisher’s version ) (Closed access)Exogenous radiolabeled annexin A5 is taken up by atherosclerotic tissue.
Heerde, W.L. van, Vleuten, G.M. van der, Grobbee, D.E., Graaf, J. de, Stalenhoef, A.F.H., Vijver, L.P.L. van de, Stalenhoef, A.F., Tits, L.J.H. van, Vijver, L.P. van de, Princen, H.M.   +9 more
core   +1 more source

Recombinant Human Annexin A5 [PDF]

Critical Care Medicine, 2014
Sepsis is characterized by activation of the innate immune response with production of massive inflammatory cytokines, which contributes to multiple organ failure and death. Pattern recognition receptors (PRRs) sense pathogen-associated molecular patterns and endogenous stress signals termed danger-associated molecular patterns to initiate a signaling ...
openaire   +2 more sources

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source