Results 41 to 50 of about 6,682 (198)

Domain IV of Annexin A5 Is Critical for Binding Calcium and Guarantees Its Maximum Binding to the Phosphatidylserine Membrane [PDF]

Molecules, 2017
Background: Although domain IV of annexin A5 (anxA5) may be less effective in binding phosphatidylserine (PS), the four domains together may guarantee the maximum binding of anxA5 to the PS membrane. Additionally, previous research has shown that annexin
Jie Wang, Jing Liu, Yulu Cao, Minjin Hu, Zichun Hua   +4 more
doaj   +2 more sources

Review: Annexin-A5 and cell membrane repair

Placenta, 2015
Annexins are soluble proteins that bind to biological membranes containing negatively charged phospholipids, principally phosphatidylserine, in a Ca2+-dependent manner.
GOUNOU, Celine, BOUTER, Anthony, BOUVET, Flora, DEGRELLE, S. A., CARMEILLE, R., EVAIN-BRION, D., BRISSON, Alain   +6 more
core   +3 more sources

Study of the Serum Level of Annexin A5 as a Marker for Hepatocellular Carcinoma in Hepatitis C Virus Cirrhosis Patients [PDF]

Afro-Egyptian Journal of Infectious and Endemic Diseases, 2023
Background and study aim: Cirrhosis is considered a risk factor for developing hepatocellular carcinoma. Hepatitis C virus infection is one of the important causes of the development of cirrhosis and hepatocellular carcinoma.
Heba El hagary
doaj   +1 more source

Anti-Annexin A5 antibodies and Annexin A5 resistance in antiphospholipid syndrome: A systematic review and meta-analysis. [PDF]

J Transl Autoimmun
Alamlih L, Becetti K, Al Emadi S, Satti E, Tag ZM, Chemaitelly H, Abu-Tineh M, Abufaied M, Laws S, Khamashta M.   +9 more
europepmc   +2 more sources

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Annexin A5 as a marker for hepatocellular carcinoma in cirrhotic hepatitis C virus patients

Egyptian Liver Journal, 2021
Background The tumorigenesis and development in a variety of cancers is reportedly encouraged via Annexin A5. The levels of Annexin A5 were tested in patients with or without HCC who were affected by liver cirrhosis.
Waleed Mohamed Serag, Basem Eysa Elsayed
doaj   +1 more source

Annexin A5 Involvement in Bone Overgrowth at the Enthesis [PDF]

Journal of Bone and Mineral Research, 2018
ABSTRACT   Little is known about the molecular mechanisms of enthesis formation in mature animals. Here, we report that annexin A5 (Anxa5) plays a critical role in the regulation of bone ridge outgrowth at the entheses.
Shimada, Akemi, Ideno, Hisashi, Arai, Yoshinori, Komatsu, Koichiro, Wada, Satoshi, Yamashita, Teruhito, Amizuka, Norio, Pöschl, Ernst, Brachvogel, Bent, Nakamura, Yoshiki, Nakashima, Kazuhisa, Mizukami, Hiroaki, Ezura, Yoichi, Nifuji, Akira   +13 more
openaire   +4 more sources

Predicting the risk of portal vein thrombosis in patients with liver cirrhosis and hepatocellular carcinoma

Heliyon, 2020
The mechanisms of the hypercoagulable state in cirrhotics with and without hepatocellular carcinoma are incompetently comprehended. Objective: We aimed to explore the plasma Annexin A5/PS + MP ratio in these patients.
Waleed Mohamed Serag, Bedoor Shehap eldeen Mohammed, Magdy Mahmoud Mohamed, Basem Eysa Elsayed   +3 more
doaj   +1 more source

The Relevance, Predictability, and Utility of Annexin A5 for Human Physiopathology. [PDF]

Int J Mol Sci
As an important functional protein molecule in the human body, human annexin A5 (hAnxA5) is widely found in human cells and body fluids. hAnxA5, the smallest type of annexin, performs a variety of biological functions by reversibly and specifically binding phosphatidylserine (PS) in a calcium-dependent manner and plays an important role in many human ...
Jing J.
europepmc   +3 more sources

Annexin A5 Increases Survival in Murine Sepsis Model by Inhibiting HMGB1-Mediated Proinflammation and Coagulation

Molecular Medicine, 2016
The identification of HMGB1 as a late mediator in sepsis has highlighted HMGB1 as a promising therapeutic target for sepsis treatment. Recent studies have revealed that annexin A5, a 35 kDa Ca2+-dependent phospholipid binding protein, exerts ...
Jung Hwa Park, Jong-Hwa Jang, Eun Jung Choi, Young Seob Kim, Eun Ji Lee, In Duk Jung, Hee Dong Han, T-C Wu, Chien-Fu Hung, Tae Heung Kang, Yeong-Min Park   +10 more
doaj   +1 more source