Results 31 to 40 of about 6,682 (198)
Evaluation of annexin A5 as a biomarker for Alzheimer's disease and Dementia with Lewy bodies
Frontiers in Aging Neuroscience, 2013 Background: Alzheimer’s disease (AD) differs from other forms of dementia in its relation to amyloid beta-42. Using a cell culture model we previously identified annexin A5 as an AD biomarker.
Hitoshi eSohma +10 more
doaj +2 more sources
Annexin A5 regulates hepatic macrophage polarization via directly targeting PKM2 and ameliorates NASH [PDF]
Redox Biology, 2020 Nonalcoholic steatohepatitis (NASH), the progressive form of nonalcoholic fatty liver disease (NAFLD), is becoming a common chronic liver disease with the characteristics of steatosis, inflammation and fibrosis.
Fang Xu +11 more
doaj +2 more sources
Molecular Imaging, 2014 [ 68 Ga]Annexin A5 positron emission tomography (PET) reveals the externalization of phosphatidylserine as a surrogate marker for apoptosis. We tested this technique for therapy monitoring in a murine model of myocardial infarction (MI) including ...
Sebastian Lehner +12 more
doaj +2 more sources
Human annexin A5 promotes glioma progression by targeting the MAPK/CD44 pathway [PDF]
Frontiers in OncologyBackgroundGliomas are the most common intracranial malignant tumors. In this study, we aimed to identify the hub genes and investigate the pathophysiological significance of ANXA5 in glioma.MethodsThe differentially expressed genes (DEGs) between tumor ...
WeiXian Liu +5 more
doaj +2 more sources
Caffeic Acid Acts as a Potent Senomorphic and Alleviates Inflammation and Lung Fibrosis by Covalently Targeting Annexin A5 Protein in Mice [PDF]
ExplorationThe accumulation of senescent cells and their secretion of senescence‐associated secretory phenotype (SASP) play important roles in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Yinhua Zhu +14 more
doaj +2 more sources
Molecular Imaging, 2013 Technetium 99m ( 99m Tc)–annexin A5, a marker of ongoing apoptosis, is supposed to be useful in the detection of metabolically active atheroma. The aim of this study was to determine the potential of 99m Tc–annexin A5 for evaluating the therapeutic ...
Yan Zhao +5 more
doaj +2 more sources
Knockdown of annexin A5 restores gefitinib sensitivity by promoting G2/M cell cycle arrest [PDF]
Respiratory Research, 2018 Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors, including gefitinib, are first-line drugs against advanced non-small cell lung cancer with activating EGFR mutations. However, the development of resistance to such drugs is a
Jian Zhou +5 more
doaj +2 more sources
Annexin A5 reduces early plaque formation in ApoE -/- mice. [PDF]
PLoS ONE, 2017 Annexin A5 (AnxA5) exerts anti-inflammatory, anticoagulant and anti-apoptotic effects through its binding to cell surface expressed phosphatidylserine. We previously showed that AnxA5 can stabilize advanced atherosclerotic plaques by reducing macrophage ...
Robert Stöhr +5 more
doaj +2 more sources
Annexin A5 is involved in migration and invasion of oral carcinoma [PDF]
Cell Cycle, 2009 Annexin A5 is a Ca2+-binding protein which is involved in membrane organization and dynamics. As recent data suggest a role of annexin A5 in cancer we aimed to gain more insight into the biological function of endogenous annexin A5 and assessed its ...
von Eggeling, Ferdinand +13 more
core +3 more sources
Annexin A5–Functionalized Nanoparticle for Multimodal Imaging of Cell Death
Molecular Imaging, 2013 Techniques for visualizing cell death can provide noninvasive assessment of both disease states and response to therapeutic intervention. The purpose of this study was to develop and evaluate a multimodal imaging nanoplatform for the detection of cell ...
Rui Zhang +5 more
doaj +2 more sources