Results 51 to 60 of about 6,682 (198)
Translation and Development of Novel Annexin A5 - Protein Drug Conjugates for the Treatment of Triple-Negative Breast Cancer [PDF]
, 2022 Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subset with limited targeted chemotherapies. TNBC is defined by the absence of the estrogen, progesterone, and HER2 hormonal receptors on the cell surface, and targeted hormonal ...
Woodward, Alexis
core
Association of annexin A5 polymorphisms with obesity
Biomedical Reports, 2013 Annexin A5 (ANXA5), which is known as a protein with anticoagulative function, may play a role in triglyceride biosynthesis. Triglycerides are involved in lipid and energy metabolism, which are important in the elucidation of obesity. To investigate the association between single-nucleotide polymorphisms (SNPs) of ANXA5 and obesity in a Korean ...
Hosik, Seok +9 more
openaire +3 more sources
Impairment of Ceramide-Mediated Endothelial Instant Membrane Resealing During Diabetes Mellitus
Frontiers in Physiology, 2022 Recent studies have indicated that instant cell membrane resealing (ICMR) controls the activation of NOD-like receptor pyrin domain containing 3 (Nlrp3) inflammasomes in endothelial cells, thereby initiating and promoting vascular inflammation.
Yang Chen +6 more
doaj +1 more source
Bending of a lipid membrane edge by annexin A5 trimers. [PDF]
Biophys JPlasma membrane damage occurs in healthy cells and more frequently in cancer cells where high growth rates and metastasis result in frequent membrane damage. The annexin family of proteins plays a key role in membrane repair. Annexins are recruited at the membrane injury site by Ca+2 and repair the damaged membrane in concert with several other ...
Pandey MP +3 more
europepmc +8 more sources
Annexin A5 stimulates autophagy and inhibits endocytosis [PDF]
Journal of Cell Science, 2012 Macroautophagy is a major lysosomal catabolic process activated particularly under starvation in eukaryotic cells. A new organelle, the autophagosome, engulfs cytoplasmic substrates, which are degraded after fusion with endosomes and/or lysosomes.
Ghislat, G, Aguado, C, Knecht, E
openaire +4 more sources
Anti-annexin as a marker in patients with recurrent miscarriages
Middle East Fertility Society Journal, 2010 Objective: To investigate the possible role of anti-annexin A5 antibodies in inducing recurrent miscarriage. Design: Cross-sectional study. Setting: Benha University Hospital.
Ahmed Rezk +3 more
doaj +1 more source
Diagnosis of portal vein thrombosis in cirrhotic patients with and without hepatocellular carcinoma
Egyptian Liver Journal, 2022 Background The levels of Annexin A5 (Annexin V) were measured in patients with and without HCC who had liver cirrhosis. These patients were followed for 12 months to determine the incidence of PVT and to determine the role of Annexin V in the diagnosis ...
Waleed M. Serag, Basem E. Eysa
doaj +1 more source
Annexin A5 Knockdown Prompts Proliferation of Gastric Cancer MKN-45 Cells
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the effect of annexin A5 knockdown on the proliferation and apoptosis of gastric cancer MKN-45 cells. Methods The gastric cancer MKN-45 cells were divided into three groups: siRNA interference group transfected with siRNA ...
ZHAO Yi'na +5 more
doaj +1 more source
Therapeutic Potential of Annexins in Sepsis and COVID-19
Frontiers in Pharmacology, 2021 Sepsis is a continuing problem in modern healthcare, with a relatively high prevalence, and a significant mortality rate worldwide. Currently, no specific anti-sepsis treatment exists despite decades of research on developing potential therapies ...
Louise Mui +5 more
doaj +1 more source
, 2008 Proteins of the annexin family bind to phospholipids in a Ca2+ dependent manner. The exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat-me-signal for macrophages.
Rodel, Franz +25 more
core +1 more source