Apoptosis, annexin A5 and anti-annexin A5 antibodies in the antiphospholipid syndrome [PDF]
Journal of Medical Biochemistry, 2013 It has been proposed that apoptosis is one of the mechanisms involved in the generation of antiphospholipid antibodies. The presence of antiphospholipid antibodies is the main laboratory criterion for a definite diagnosis of the antiphospholipid syndrome.
Bećarević Mirjana +2 more
doaj +6 more sources
American Journal of Obstetrics and Gynecology, 2006 Item does not contain fulltextOBJECTIVE: We investigated whether levels of annexin A5, evidence for resistance to annexin A5 activity, and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy ...
Jacob H Rand +2 more
exaly +5 more sources
Recombinant human annexin A5 accelerates diabetic wounds healing by regulating skin inflammation [PDF]
Regenerative TherapyBackground: One of the key obstacles to the healing of diabetic wound is the persistence of active inflammation. We previously demonstrated the potential of cell-free fat extract (CEFFE) to promote the healing of diabetic wounds, and annexin A5 (A5) is a
Bijun Kang +4 more
doaj +3 more sources
Development and evaluation of a novel (99m)tc-labeled annexin A5 for early detection of response to chemotherapy. [PDF]
PLoS ONE, 2013 (99m)Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99m)Tc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem,
Kazuma Ogawa +11 more
doaj +5 more sources
Annexin A5 stabilizes matrix vesicle-biomimetic lipid membranes: unravelling a new role of annexins in calcification. [PDF]
Eur Biophys J, 2023 Matrix vesicles are a special class of extracellular vesicles thought to actively contribute to both physiologic and pathologic mineralization. Proteomic studies have shown that matrix vesicles possess high amounts of annexin A5, suggesting that the ...
Ferreira CR +7 more
europepmc +2 more sources
Molecular imaging of cell death in tumors. Increasing annexin A5 size reduces contribution of phosphatidylserine-targeting function to tumor uptake. [PDF]
PLoS ONE, 2014 OBJECTIVE: Annexin A5 is a phosphatidylserine binding protein that binds dying cells in vivo. Annexin A5 is a potential molecular imaging agent to determine efficacy of anti-cancer therapy in patients.
Lisette Ungethüm +4 more
doaj +2 more sources
Preliminary Biological Evaluation of Novel 99mTc-Cys-Annexin A5 as a Apoptosis Imaging Agent
Molecules, 2013 A novel annexin A5 derivative (cys-annexin A5) with a single cysteine residue at its C-terminal has been developed and successfully labeled in high labeling yield with 99mTc by a ligand exchange reaction.
Zichun Hua +6 more
doaj +2 more sources
Pharmacokinetics of recombinant human annexin A5 (SY-005) in patients with severe COVID-19 [PDF]
Frontiers in Pharmacology, 2023 Objective: Annexin A5 is a phosphatidylserine binding protein with anti-inflammatory, anticoagulant and anti-apoptotic properties. Preclinical studies have shown that annexin A5 inhibits pro-inflammatory responses and improves organ function and survival
Brent J. Tschirhart +16 more
doaj +2 more sources
Annexin A5 prevents amyloid-β-induced toxicity in choroid plexus: implication for Alzheimer's disease. [PDF]
Sci Rep, 2020 In Alzheimer’s disease (AD) amyloid-β (Aβ) deposits may cause impairments in choroid plexus, a specialised brain structure which forms the blood–cerebrospinal fluid (CSF) barrier.
Bartolome F +14 more
europepmc +4 more sources
Annexin A1 and annexin A5 in cardiovascular disease [PDF]
, 2015 This study involves two members of the annexin family of proteins and their relationship to cardiovascular disease. The main findings are the inhibiting effect of annexin A5 on clearing away dead cells and, therefore, the enhancing effect on ...
Kusters, D.H.M.
core +2 more sources