Results 21 to 30 of about 6,682 (198)

Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization [PDF]

Bone Research, 2023
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcified osteoarthritis and in wound repair of the skeletal system due to their membranous vesicle characteristics and abundant calcium ...
Guanyue Su, Demao Zhang, Tiantian Li, Tong Pei, Jie Yang, Shasha Tu, Sijun Liu, Jie Ren, Yaojia Zhang, Mengmeng Duan, Xinrui Yang, Yang Shen, Chenchen Zhou, Jing Xie, Xiaoheng Liu   +14 more
doaj   +2 more sources

Annexin A5 regulates Leydig cell testosterone production via ERK1/2 pathway

Asian Journal of Andrology, 2016
This study was to investigate the effect of annexin A5 on testosterone secretion from primary rat Leydig cells and the underlying mechanisms. Isolated rat Leydig cells were treated with annexin A5.
Ze He, Qin Sun, Yuan-Jiao Liang, Li Chen, Yi-Feng Ge, Shi-Feng Yun, Bing Yao   +6 more
doaj   +2 more sources

Annexin A5 in Patients With Severe COVID-19 Disease: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Feasibility Trial [PDF]

Critical Care Explorations, 2023
OBJECTIVES:. To evaluate the study design and feasibility of drug administration and safety in a randomized clinical trial of recombinant human annexin A5 (SY-005), a constitutively expressed protein with anti-inflammatory, antiapoptotic, and ...
Claudio M. Martin, MD, Marat Slessarev, MD, PhD, Eileen Campbell, John Basmaji, MD, Ian Ball, MD, Douglas D. Fraser, MD, PhD, Aleksandra Leligdowicz, MD, PhD, Tina Mele, MD, PhD, Fran Priestap, MSc, Brent J. Tschirhart, MSc, Tracey Bentall, RN, Xiangru Lu, MD, Qingping Feng, MD, PhD   +12 more
doaj   +2 more sources

Annexin A5 is not essential for skeletal development [PDF]

Molecular and Cellular Biology, 2003
Annexins are highly conserved proteins that are characterized by their ability to interact with phospholipids in a calcium-dependent manner. Although diverse functions have been ascribed to annexins based on in vitro analyses, their in vivo functions ...
Welzel, Heike, Brachvogel, Bent, Moch, Helga, Hofmann, Clementine, Dikschas, Jörg, Poschl, Ernst, von der Mark, Klaus   +6 more
core   +4 more sources

New Therapeutic Strategies in Retinal Vascular Diseases: A Lipid Target, Phosphatidylserine, and Annexin A5—A Future Theranostic Pairing in Ophthalmology [PDF]

Pharmaceuticals
Despite progress in the management of patients with retinal vascular and degenerative diseases, there is still an unmet clinical need for safe and effective therapeutic options with novel mechanisms of action.
Anna Frostegård, Anders Haegerstrand
doaj   +2 more sources

Annexin A5 polymorphism (-1C-->T) and the presence of anti-annexin A5 antibodies in the antiphospholipid syndrome. [PDF]

Annals of the Rheumatic Diseases, 2006
Item does not contain fulltextBACKGROUND: Annexin A5 is thought to have a role in the pathophysiology of the antiphospholipid syndrome (APS)-a syndrome characterised by recurrent thrombosis and pregnancy morbidity.
B J Woodhams, Woodhams, B.J., M Roest, W L van Heerde, S Schoormans, Roest, M., R H W M Derksen, Schoormans, S.C.M., Laat, B. de, I J Mackie, Heerde, W.L. van, Derksen, R.H.W.M., Groot, P.G. de, Mackie, I.J., B de Laat, P G de Groot   +15 more
core   +4 more sources

Annexin A5 Protects SH-SY5Y Cells against L-Glutamate-Induced Cytotoxicity [PDF]

Iranian Journal of Medical Sciences
Background: L- glutamate- induced neurotoxicity is linked to neuronal loss in neurodegenerative diseases and stroke. Annexin A5 (ANXA5) is a cytosolic protein that binds calcium in eukaryotic organisms. This study aimed to evaluate the protective effects
Zahra Abedini, Marzieh Mehdieh, Mohammad Ali Takhshid   +2 more
doaj   +2 more sources

Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis

Scientific Reports, 2023
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore, the identification of new early biomarkers could help reduce mortality.
Ema Elvira Herrera-López, Dafne Guerrero-Escalera, Isaac Aguirre-Maldonado, Arely López-Hernández, Hilda Montero, María Angélica Gutiérrez‐Nava, Luis del Pozo-Yauner, Jaime Arellanes-Robledo, Javier Camacho, Julio Isael Pérez-Carreón   +9 more
doaj   +3 more sources

Annexin A5 Inhibits Endothelial Inflammation Induced by Lipopolysaccharide-Activated Platelets and Microvesicles via Phosphatidylserine Binding [PDF]

Pharmaceuticals, 2023
Sepsis is caused by a dysregulated immune response to infection and is a leading cause of mortality globally. To date, no specific therapeutics are available to treat the underlying septic response. We and others have shown that recombinant human annexin
Brent J. Tschirhart, Xiangru Lu, Janice Gomes, Arundhasa Chandrabalan, Gillian Bell, David A. Hess, Guangxin Xing, Hong Ling, Dylan Burger, Qingping Feng   +9 more
doaj   +2 more sources

Preclinical Validation of Tc–Annexin A5–128 in Experimental Autoimmune Myocarditis and Infective Endocarditis: Comparison with Tc–HYNIC–Annexin A5

Molecular Imaging, 2015
Hydrazinonicotinamide–annexin A5 (HYNIC-Anx), a 99m technetium ( 99m Tc)-labeled agent targeting phosphatidylserine, proved to be sensitive for the detection of apoptosis and thrombosis but is no longer available for clinical use.
Khadija Benali, Liliane Louedec, Rana Ben Azzouna, Olivier Merceron, Pierre Nassar, Faisal Al Shoukr, Anne Petiet, Donato Barbato, Jean-Baptiste Michel, Laure Sarda-Mantel, Dominique Le Guludec, Francois Rouzet   +11 more
doaj   +2 more sources