Annexins—a family of proteins with distinctive tastes for cell signaling and membrane dynamics [PDF]
Nature CommunicationsAnnexins are cytosolic proteins with conserved three-dimensional structures that bind acidic phospholipids in cellular membranes at elevated Ca2+ levels.
Volker Gerke, Felicity N E Gavins
exaly +4 more sources
Therapeutic Potential of Annexins in Sepsis and COVID-19
Frontiers in Pharmacology, 2021 Sepsis is a continuing problem in modern healthcare, with a relatively high prevalence, and a significant mortality rate worldwide. Currently, no specific anti-sepsis treatment exists despite decades of research on developing potential therapies ...
Louise Mui +5 more
doaj +2 more sources
Annexins and cardiovascular diseases: Beyond membrane trafficking and repair
Frontiers in Cell and Developmental Biology, 2022 Cardiovascular diseases (CVD) remain the leading cause of mortality worldwide. The main cause underlying CVD is associated with the pathological remodeling of the vascular wall, involving several cell types, including endothelial cells, vascular smooth ...
Nerea Méndez-Barbero +10 more
doaj +2 more sources
Bioinformatics analysis of bacterial annexins--putative ancestral relatives of eukaryotic annexins. [PDF]
PLoS ONE, 2014 Annexins are Ca(2+)-binding, membrane-interacting proteins, widespread among eukaryotes, consisting usually of four structurally similar repeated domains. It is accepted that vertebrate annexins derive from a double genome duplication event.
Praveen Kumar Kodavali +3 more
doaj +2 more sources
Revisiting the role of Annexins in membrane trafficking [PDF]
Cellular and Molecular Life SciencesEver since their discovery five decades ago, annexins have been implicated in membrane-related events along endo- and exocytic pathways. Over the years, structural, biochemical and cell imaging studies have revealed that annexins facilitate the ...
Thomas Grewal +4 more
doaj +2 more sources
The role of annexins in central nervous system development and disease. [PDF]
J Mol Med (Berl)Annexins, a group of Ca2+-dependent phospholipid-binding proteins, exert diverse roles in neuronal development, normal central nervous system (CNS) functioning, neurological disorders, and CNS tumors.
White ZB, Nair S, Bredel M.
europepmc +2 more sources
Unconventional secretion of annexins and galectins
Seminars in Cell and Developmental Biology, 2018 Eukaryotic cells have a highly evolved system of protein secretion, and dysfunction in this pathway is associated with many diseases including cancer, infection, metabolic disease and neurological disorders.
Sarah E Stewart, Kevin Moreau
exaly +2 more sources
Comparative Cell Biology and Evolution of Annexins in Diplomonads
mSphere, 2016 Annexins are multifunctional, calcium-binding proteins found in organisms across all kingdoms. Most studies of annexins from single-celled eukaryotes have focused on the alpha-giardins, proteins assigned to the group E annexins, expressed by the ...
Elin Einarsson +5 more
doaj +2 more sources
Annexins: central regulators of plant growth and stress signaling [PDF]
Acta Biochimica et Biophysica SinicaAnnexins are a family of multifunctional calcium-dependent and phospholipid-binding proteins that are widely distributed in the plant kingdom. They have a highly conserved evolutionary history that dates back to single-celled protists. Plant annexins, as
Xie Chen +5 more
doaj +2 more sources
Arabidopsis fad4 mutant analysis provides insights into thermo sensing within plant plasma membrane [PDF]
Frontiers in Plant ScienceIncreasing evidence suggests that the plasma membrane is the initial site for temperature sensing. In searching for the contributions of membrane lipids to stress-induced cytosolic calcium, we found that FATTY ACID DESATURASE 4 (FAD4) knockout mutant ...
Mingjie Chen +6 more
doaj +2 more sources