Results 181 to 190 of about 8,763 (208)
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Role of ANO1 in tumors and tumor immunity
Journal of Cancer Research and Clinical Oncology, 2022Dysregulation of gene amplification, cell-signaling-pathway transduction, epigenetic and transcriptional regulation, and protein interactions drives tumor-cell proliferation and invasion, while ion channels also play an important role in the generation and development of tumor cells.
Xueguo Sun, Xu Hua, Zongtao Liu
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Experimental and Molecular Pathology, 2020 Long non-coding RNAs (lncRNAs) have a particular expression in the testicular tissue and exhibit a regulatory function on the reproduction system. ANO1-AS2 (linc02584), as an lncRNA is located near the anoctamin1 (ANO1) gene. ANO1 is an important component of the transmembrane system exhibiting expression modifications in the idiopathic infertile men ...
Mohammadreza Saberiyan +2 more
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Involvement of TMEM16A/ANO1 upregulation in the oncogenesis of colorectal cancer
Biochimica Et Biophysica Acta - Molecular Basis of Disease, 2022The Ca2+-activated Cl- channel ANO1 is widely expressed in epithelial cells, and ANO1 upregulation is implicated in the oncogenesis of many epithelium-originated cancers. However, whether ANO1 plays a causal role in the tumorigenesis of colorectal cancer remains largely unknown. Here, we show that ANO1 channel protein is upregulated in human colorectal
Chunhua Han, Zongtao Liu, Yani Liu
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TMEM16A (ANO1) as a therapeutic target in cystic fibrosis
Current Opinion in Pharmacology, 2022Cystic fibrosis (CF) is a multi-organ genetic disease caused by loss of function of CFTR, a cAMP-regulated chloride channel expressed in epithelial cells. In airway epithelia, CFTR-dependent chloride secretion is required to humidify mucosal surface and to allow efficient mucociliary clearance.
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Regulation of ANO1/TMEM16A anion permeability
Pancreatology, 2013Background/aim: Bicarbonate (HCO3 ) is an important ingredient in many biological fluids including saliva. However, calcium activated chlo ride channels (CaCCs) in salivary gland acinar cells are known to be poorly permeable to HCO3 in most cases. Methods: To elucidate the possibility of ANO1 as a HCO3 channel, anion currents were measured in HEK 293T ...
Jinsei Jung +5 more
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Understanding the Role of ANO1 in Oral Cancer
2021In 2008, the gene ANO1 was discovered to encode a calcium activated chloride channel. This gene is located on the 11q13 locus, a locus that is commonly amplified in many cancers including cancer of the head and neck. ANO1 is situated in close proximity to genes associated with growth and apoptosis.
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Involvement of TRPV1-ANO1 Interactions in Pain-Enhancing Mechanisms
2018Primary sensory neurons detect potentially dangerous environmental situations via many "sensor" proteins located on the plasma membrane. Although receptor-type cation channels are thought to be the major sensors in sensory neurons, anion channels are also important players in the peripheral nervous system.
Y, Takayama, Makoto, Tominaga
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Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1
Cellular Signalling, 2018Airway epithelial cells express both Ca2+ activated TMEM16A/ANO1 and cAMP activated CFTR anion channels. Previous work suggested a significant crosstalk of intracellular Ca2+ and cAMP signaling pathways, leading to activation of both chloride channels.
Joana Lérias +6 more
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