Results 61 to 70 of about 107,476,558 (181)

A proteomic investigation of forebrain regeneration in the leopard gecko (Eublepharis macularius)

Developmental Dynamics, EarlyView.
Our investigation reveals ontogenetic, injury‐ and regeneration‐associated proteomic changes in the leopard gecko forebrain. Abstract Background The ability to replace lost or damaged neurons following an injury is termed reactive neurogenesis. Although reactive neurogenesis has been reported in several lizard species, the molecular mechanisms ...
Alexandra I. Noble, Samantha L. Payne, Matthew K. Vickaryous   +2 more
wiley   +1 more source

Anoctamin‐1 is expressed and functional in the Pulmonary Vascular Endothelium

The FASEB Journal, 2013
Background and Objective The expression and functional role of Anoctamin‐1 (ANO1), a Ca2+ activated Cl channel in the endothelial cells (EC) is unclear. We sought to confirm the presence of ANO1 in the pulmonary vascular EC (PVEC) and the effect of ANO1 activation on EC membrane potential (Vm).
Ayed Mamdouh Allawzi, Alexander Vang, Anlong Li, Gaurav Choudhary   +3 more
openaire   +1 more source

A CLCA regulatory protein present in the chemosensory cilia of olfactory sensory neurons induces a Ca2+-activated Cl− current when transfected into HEK293

BMC Neuroscience, 2017
Background CLCA is a family of metalloproteases that regulate Ca2+-activated Cl− fluxes in epithelial tissues. In HEK293 cells, CLCA1 promotes membrane expression of an endogenous Anoctamin 1 (ANO1, also termed TMEM16A)-dependent Ca2+-activated Cl ...
Casilda V. Mura, Ricardo Delgado, María Graciela Delgado, Diego Restrepo, Juan Bacigalupo   +4 more
doaj   +1 more source

Triggered Calcium Lightning Programs Cochlear Development

Exploration, EarlyView.
Summary: Before the onset of hearing, the developing inner ear generates spontaneous calcium signals that are thought to guide maturation. In this study, we discovered a rapid and widespread calcium flash—dubbed “Ca2+ lightning”—originating from supporting cells beneath the sensory hair cells, which triggers coordinated calcium waves across the entire ...
Qiang Ma, Hai‐Peng Wang, Yu‐Meng Jiang, Ke Lai, Ming‐Xian Li, Zhen Zhang, Li‐Na Gong, Jing‐Wei Lai, Kai‐Ming Su, Lu‐Yang Wang, Hui Wang, Shan‐Kai Yin, Hao He, Hai‐Bo Shi   +13 more
wiley   +1 more source

Antibodies against the flotillin-1/2 complex in patients with multiple sclerosis [PDF]

, 2023
Lleixa and Caballero-avila et al. report that antibodies targeting the flotillin-1/2 complex are present in a subgroup of patients with multiple sclerosis. Further studies are needed to understand the clinical and pathological relevance of anti-flotillin-
Martínez Yélamos, Sergio, Brieva Ruiz, Luis, Martín Aguilar, Lorena, Franco Leyva, Teresa, Cortés-Vicente, Elena, Collet Vidiella, Roger, Martín-Aguilar, Lorena, Vesperinas, Ana, Caballero Ávila, Marta, Rojas García, Ricard, Vesperinas-Castro, Ana, Caballero-Ávila, Marta, Valdés-Hevia, Eduardo, Martinez-Martinez, Laura, Pascual-Goñi, Elba, Gómez Anson, Beatriz, Cortés Vicente, Elena, Moga, Esther, González Mingot, Cristina, Lleixà, Cinta, Valdés Hevia, Eduardo, Gil, Anna, Martínez Martínez, Laura, Vidal, Nuria, Zárate, Elisa, Pascual Goñi, Elba, Tejada, Clara, Brieva, Luis, Rojas-Garcia, Ricard, González-Mingot, Cristina, Querol, Luis, Collet, Roger, Tejada-Illa, Clara   +32 more
core   +1 more source

Anoctamin 2/TMEM16B: A calcium-activated chloride channel in olfactory transduction [PDF]

, 2012
In vertebrate olfactory transduction, a Ca2+-dependent Cl- efflux greatly amplifies the odorant response. The binding of odorants to receptors in the cilia of olfactory sensory neurons activates a transduction cascade that involves the opening of cyclic ...
Pifferi S., Cenedese V., Menini A.
core   +2 more sources

The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

Acta Pharmaceutica Sinica B, 2021
Anoctamin 1 (ANO1) or TMEM16A gene encodes a member of Ca2+ activated Cl– channels (CaCCs) that are critical for physiological functions, such as epithelial secretion, smooth muscle contraction and sensory signal transduction. The attraction and interest
Yani Liu, Zongtao Liu, KeWei Wang
doaj   +1 more source

Neuronal and ion channel mechanisms of noxious heat sensing in mammals: A puzzle of sensory physiology and pharmacology

British Journal of Pharmacology, EarlyView.
Transient receptor potential vanilloid 1 (TRPV1) was the first noxious heat‐sensitive channel discovered. In rodents, its role is robust in the heat response of the cell body of polymodal nociceptors, but surprisingly small in that of the peripheral terminals in the skin.
Gábor Pethő, Peter W. Reeh
wiley   +1 more source

Anoctamin 1, a multi-modal player in pain and itch

Cell Calcium
Anoctamin 1 (ANO1/TMEM16A) encodes a Ca2+-activated Cl- channel. Among ANO1's many physiological functions, it plays a significant role in mediating nociception and itch. ANO1 is activated by intracellular Ca2+ and depolarization. Additionally, ANO1 is activated by heat above 44 °C, suggesting heat as another activation stimulus.
Hyungsup Kim, Won-Sik Shim, Uhtaek Oh
openaire   +2 more sources

Ion Channel Dysfunction and Therapeutic Targeting in Salivary Gland Disorders

Oral Diseases, EarlyView.
ABSTRACT Objective Salivary gland hypofunction and xerostomia represent major clinical complications of radiation therapy, autoimmune disorders such as Sjögren's disease, and inherited epithelial ion transport defects. This review integrates current knowledge on ion channel dysfunction as a central mechanistic driver of salivary gland pathology and ...
Tarek Mohamed Abd El‐Aziz, Shankara N. Varadarajan, Viktor Drel, Prakash Arullampalam, Mahmoud I. Shoulkamy, Ahmed Al‐Sabi, Brij B. Singh   +6 more
wiley   +1 more source